Cargando…

Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide

Capsaicin, a transient receptor potential vanilloid type 1 (TRPV1) ligand, regulates nerve-related pain-sensitive signals, inflammation, and cancer growth. Capsaicin suppresses interleukin-1-induced osteoclast differentiation, but its roles in bone tissues and bone diseases are not known. This study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kobayashi, Megumi, Watanabe, Kenta, Yokoyama, Satoshi, Matsumoto, Chiho, Hirata, Michiko, Tominari, Tsukasa, Inada, Masaki, Miyaura, Chisato
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scholarly Research Network 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324930/ https://www.ncbi.nlm.nih.gov/pubmed/22548186 http://dx.doi.org/10.5402/2012/439860

Ejemplares similares

Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice
por: Tominari, Tsukasa, et al.
Publicado: (2015)

Endosomal TLR3 signaling in stromal osteoblasts induces prostaglandin E(2)–mediated inflammatory periodontal bone resorption
por: Tominari, Tsukasa, et al.
Publicado: (2022)

Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption
por: Watanabe, Kenta, et al.
Publicado: (2017)

Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts
por: Tominari, Tsukasa, et al.
Publicado: (2021)

Effects of O‐methylated (−)‐epigallocatechin gallate (EGCG) on LPS‐induced osteoclastogenesis, bone resorption, and alveolar bone loss in mice
por: Tominari, Tsukasa, et al.
Publicado: (2017)

Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity
por: Hirata, Narumi, et al.
Publicado: (2019)

Effects of Polymethoxyflavonoids on Bone Loss Induced by Estrogen Deficiency and by LPS-Dependent Inflammation in Mice
por: Matsumoto, Shigeru, et al.
Publicado: (2018)

An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2–mediated Bone Resorption Associated with Inflammation
por: Miyaura, Chisato, et al.
Publicado: (2003)

Effects of 4′-Demethylnobiletin and 4′-Demethyltangeretin on Osteoclast Differentiation In Vitro and in a Mouse Model of Estrogen-Deficient Bone Resorption
por: Hirata, Michiko, et al.
Publicado: (2023)

Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice
por: Tominari, Tsukasa, et al.
Publicado: (2019)

A mouse model of lung cancer induced via intranasal injection for anticancer drug screening and evaluation of pathology
por: Tanaka, Ryo, et al.
Publicado: (2022)

Lymphokine-mediated bone resorption requires endogenous prostaglandin synthesis
Publicado: (1981)

Osteoclastic bone resorption directly activates osteoblast function
por: Udagawa, Nobuyuki
Publicado: (2012)

Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption
por: Cawley, Keisha M., et al.
Publicado: (2020)

Possible role of S-equol on bone loss via amelioration of inflammatory indices in ovariectomized mice
por: Nishide, Yoriko, et al.
Publicado: (2013)

TRPV6 is a potential regulator of bone resorption in bone loss induced by estrogen deficiency
por: Ma, Jun, et al.
Publicado: (2021)

Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro
por: Costa, Jessica L., et al.
Publicado: (2011)

Combined Effects of Soy Isoflavones and β-Carotene on Osteoblast Differentiation
por: Nishide, Yoriko, et al.
Publicado: (2015)

Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts
Publicado: (1986)

TRANCE Is Necessary and Sufficient for Osteoblast-mediated Activation of Bone Resorption in Osteoclasts
por: Fuller, Karen, et al.
Publicado: (1998)

Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo
por: Uenaka, Maki, et al.
Publicado: (2022)

The Combination of Soy Isoflavones and Resveratrol Preserve Bone Mineral Density in Hindlimb-Unloaded Mice
por: Tousen, Yuko, et al.
Publicado: (2020)

Eldecalcitol effects on osteoblastic differentiation and function in the presence or absence of osteoclastic bone resorption
por: Bu, Jie, et al.
Publicado: (2019)

Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia
por: Kuchimaru, Takahiro, et al.
Publicado: (2014)

Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption
por: Lee, So-Youn, et al.
Publicado: (2018)

Neuronal TRPV1 activation regulates alveolar bone resorption by suppressing osteoclastogenesis via CGRP
por: Takahashi, Naoki, et al.
Publicado: (2016)

Porphyromonas gingivalis infection increases osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model
por: Zhang, Wenjian, et al.
Publicado: (2014)

Increased Osteoblastic Cxcl9 Contributes to the Uncoupled Bone Formation and Resorption in Postmenopausal Osteoporosis
por: Liu, Zezheng, et al.
Publicado: (2020)

B. abortus Infection Promotes an Imbalance in the Adipocyte–Osteoblast Crosstalk Favoring Bone Resorption
por: Freiberger, Rosa Nicole, et al.
Publicado: (2023)

Integrating TRPV1 Receptor Function with Capsaicin Psychophysics
por: Smutzer, Gregory, et al.
Publicado: (2016)

Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption
por: Niu, Chenguang, et al.
Publicado: (2017)

Factors and Mechanisms Involved in the Coupling from Bone Resorption to Formation: How Osteoclasts Talk to Osteoblasts
por: Ikeda, Kyoji, et al.
Publicado: (2014)

Enhancement of Osteoclastic Bone Resorption and Suppression of Osteoblastic Bone Formation in Response to Reduced Mechanical Stress Do Not Occur in the Absence of Osteopontin
por: Ishijima, Muneaki, et al.
Publicado: (2001)

Boric acid inhibits alveolar bone loss in rat experimental periodontitis through diminished bone resorption and enhanced osteoblast formation
por: Shalehin, Nazmus, et al.
Publicado: (2020)

Acidification of rat TRPV1 alters the kinetics of capsaicin responses
por: Neelands, Torben R, et al.
Publicado: (2005)

Ca(2+)/Calmodulin Modulates TRPV1 Activation by Capsaicin
por: Rosenbaum, Tamara, et al.
Publicado: (2004)

Rational discovery of new capsaicin analogues as TRPV1 activators
por: Cáceres, Javier, et al.
Publicado: (2015)

Lactate is a potent inhibitor of the capsaicin receptor TRPV1
por: de la Roche, Jeanne, et al.
Publicado: (2016)

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin
por: Yang, Fan, et al.
Publicado: (2017)

Voltage-Dependent Interaction of Capsaicine and Protons on TRPV1-Receptors
por: Tsvetkov, E.A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tbes8it8p0hfgqetfg0tvvbntl