A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism

The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (...

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Autores principales: CADONI, G., BOCCIA, S., PETRELLI, L., DI GIANNANTONIO, P., ARZANI, D., GIORGIO, A., DE FEO, E., PANDOLFINI, M., GALLÌ, P., PALUDETTI, G., RICCIARDI, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore SpA 2012
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Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324962/
https://www.ncbi.nlm.nih.gov/pubmed/22500060
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author CADONI, G.
BOCCIA, S.
PETRELLI, L.
DI GIANNANTONIO, P.
ARZANI, D.
GIORGIO, A.
DE FEO, E.
PANDOLFINI, M.
GALLÌ, P.
PALUDETTI, G.
RICCIARDI, G.
author_facet CADONI, G.
BOCCIA, S.
PETRELLI, L.
DI GIANNANTONIO, P.
ARZANI, D.
GIORGIO, A.
DE FEO, E.
PANDOLFINI, M.
GALLÌ, P.
PALUDETTI, G.
RICCIARDI, G.
author_sort CADONI, G.
collection PubMed
description The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).
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spelling pubmed-33249622012-04-12 A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism CADONI, G. BOCCIA, S. PETRELLI, L. DI GIANNANTONIO, P. ARZANI, D. GIORGIO, A. DE FEO, E. PANDOLFINI, M. GALLÌ, P. PALUDETTI, G. RICCIARDI, G. Acta Otorhinolaryngol Ital Review Article The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698). Pacini Editore SpA 2012-02 /pmc/articles/PMC3324962/ /pubmed/22500060 Text en © Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review Article
CADONI, G.
BOCCIA, S.
PETRELLI, L.
DI GIANNANTONIO, P.
ARZANI, D.
GIORGIO, A.
DE FEO, E.
PANDOLFINI, M.
GALLÌ, P.
PALUDETTI, G.
RICCIARDI, G.
A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism
title A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism
title_full A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism
title_fullStr A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism
title_full_unstemmed A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism
title_short A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism
title_sort review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324962/
https://www.ncbi.nlm.nih.gov/pubmed/22500060
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