Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure

[Image: see text] Focused libraries of enamine derivatives with a nonacidic, nonelectrophilic core structure were screened for inhibitors of dual-specificity protein phosphatases, and an o-hydroxybenzyl derivative RE44 (10d) was identified as a selective inhibitor of CDC25A/B. This inhibitor induced...

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Detalles Bibliográficos
Autores principales: Tsuchiya, Ayako, Hirai, Go, Koyama, Yusuke, Oonuma, Kana, Otani, Yuko, Osada, Hiroyuki, Sodeoka, Mikiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324983/
https://www.ncbi.nlm.nih.gov/pubmed/22506091
http://dx.doi.org/10.1021/ml2002778

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