Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods

[Image: see text] Malaria is responsible for approximately 1 million deaths annually; thus, continued efforts to discover new antimalarials are required. A HTS screen was established to identify novel inhibitors of the parasite's mitochondrial enzyme NADH:quinone oxidoreductase (PfNDH2). On the...

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Detalles Bibliográficos
Autores principales: Sharma, Raman, Lawrenson, Alexandre S., Fisher, Nicholas E., Warman, Ashley J., Shone, Alison E., Hill, Alasdair, Mbekeani, Alison, Pidathala, Chandrakala, Amewu, Richard K., Leung, Suet, Gibbons, Peter, Hong, David W., Stocks, Paul, Nixon, Gemma L., Chadwick, James, Shearer, Joanne, Gowers, Ian, Cronk, David, Parel, Serge P., O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A., Berry, Neil G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324984/
https://www.ncbi.nlm.nih.gov/pubmed/22380711
http://dx.doi.org/10.1021/jm3001482

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