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Clarithromycin-induced rhabdomyolysis: a case report
Rhabdomyolysis is a clinical and laboratory syndrome that is caused by various etiologies, involving the skeletal muscle. Clarithromycin, like other macrolides, is an inhibitor of CYP450 3A4, the major enzyme responsible for the metabolism of several drugs, in particular some statins. Rhabdomyolysis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325014/ https://www.ncbi.nlm.nih.gov/pubmed/22505827 http://dx.doi.org/10.2147/IJGM.S29845 |
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author | Pasqualetti, Giuseppe Bini, Giacomo Tognini, Sara Polini, Antonio Monzani, Fabio |
author_facet | Pasqualetti, Giuseppe Bini, Giacomo Tognini, Sara Polini, Antonio Monzani, Fabio |
author_sort | Pasqualetti, Giuseppe |
collection | PubMed |
description | Rhabdomyolysis is a clinical and laboratory syndrome that is caused by various etiologies, involving the skeletal muscle. Clarithromycin, like other macrolides, is an inhibitor of CYP450 3A4, the major enzyme responsible for the metabolism of several drugs, in particular some statins. Rhabdomyolysis related to macrolide–statin interaction has previously been described. To date, rhabdomyolysis induced by clarithromycin has been described in only one previous report. We describe the case of a 90-year-old Caucasian male, admitted to the University Hospital of Pisa for dyspnea, who developed rhabdomyolysis associated with clarithromycin administration. |
format | Online Article Text |
id | pubmed-3325014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33250142012-04-13 Clarithromycin-induced rhabdomyolysis: a case report Pasqualetti, Giuseppe Bini, Giacomo Tognini, Sara Polini, Antonio Monzani, Fabio Int J Gen Med Case Report Rhabdomyolysis is a clinical and laboratory syndrome that is caused by various etiologies, involving the skeletal muscle. Clarithromycin, like other macrolides, is an inhibitor of CYP450 3A4, the major enzyme responsible for the metabolism of several drugs, in particular some statins. Rhabdomyolysis related to macrolide–statin interaction has previously been described. To date, rhabdomyolysis induced by clarithromycin has been described in only one previous report. We describe the case of a 90-year-old Caucasian male, admitted to the University Hospital of Pisa for dyspnea, who developed rhabdomyolysis associated with clarithromycin administration. Dove Medical Press 2012-03-20 /pmc/articles/PMC3325014/ /pubmed/22505827 http://dx.doi.org/10.2147/IJGM.S29845 Text en © 2012 Pasqualetti et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Case Report Pasqualetti, Giuseppe Bini, Giacomo Tognini, Sara Polini, Antonio Monzani, Fabio Clarithromycin-induced rhabdomyolysis: a case report |
title | Clarithromycin-induced rhabdomyolysis: a case report |
title_full | Clarithromycin-induced rhabdomyolysis: a case report |
title_fullStr | Clarithromycin-induced rhabdomyolysis: a case report |
title_full_unstemmed | Clarithromycin-induced rhabdomyolysis: a case report |
title_short | Clarithromycin-induced rhabdomyolysis: a case report |
title_sort | clarithromycin-induced rhabdomyolysis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325014/ https://www.ncbi.nlm.nih.gov/pubmed/22505827 http://dx.doi.org/10.2147/IJGM.S29845 |
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