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Dissection of Pol II Trigger Loop Function and Pol II Activity–Dependent Control of Start Site Selection In Vivo
Structural and biochemical studies have revealed the importance of a conserved, mobile domain of RNA Polymerase II (Pol II), the Trigger Loop (TL), in substrate selection and catalysis. The relative contributions of different residues within the TL to Pol II function and how Pol II activity defects...
Autores principales: | Kaplan, Craig D., Jin, Huiyan, Zhang, Ivan Liang, Belyanin, Andrey |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325174/ https://www.ncbi.nlm.nih.gov/pubmed/22511879 http://dx.doi.org/10.1371/journal.pgen.1002627 |
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