Cargando…

Structural and Functional Diversity of Acidic Scorpion Potassium Channel Toxins

BACKGROUND: Although the basic scorpion K(+) channel toxins (KTxs) are well-known pharmacological tools and potential drug candidates, characterization the acidic KTxs still has the great significance for their potential selectivity towards different K(+) channel subtypes. Unfortunately, research on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zong-Yun, Zeng, Dan-Yun, Hu, You-Tian, He, Ya-Wen, Pan, Na, Ding, Jiu-Ping, Cao, Zhi-Jian, Liu, Mai-Li, Li, Wen-Xin, Yi, Hong, Jiang, Ling, Wu, Ying-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325286/ https://www.ncbi.nlm.nih.gov/pubmed/22511981 http://dx.doi.org/10.1371/journal.pone.0035154

Ejemplares similares

The scorpion toxin and the potassium channel
por: Swartz, Kenton J
Publicado: (2013)

Diverse Structural Features of Potassium Channels Characterized by Scorpion Toxins as Molecular Probes
por: Zhao, Yonghui, et al.
Publicado: (2019)

Kalium: a database of potassium channel toxins from scorpion venom
por: Kuzmenkov, Alexey I., et al.
Publicado: (2016)

Genomic and Structural Characterization of Kunitz-Type Peptide LmKTT-1a Highlights Diversity and Evolution of Scorpion Potassium Channel Toxins
por: Chen, Zongyun, et al.
Publicado: (2013)

Scorpion Toxins Specific for Potassium (K(+)) Channels: A Historical Overview of Peptide Bioengineering
por: Bergeron, Zachary L., et al.
Publicado: (2012)

Fluorescent protein-scorpion toxin chimera is a convenient molecular tool for studies of potassium channels
por: Kuzmenkov, Alexey I., et al.
Publicado: (2016)

The Mesobuthus martensii genome reveals the molecular diversity of scorpion toxins
por: Ma, Jianjie, et al.
Publicado: (2014)

Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2
por: Hu, You-Tian, et al.
Publicado: (2014)

A single conserved basic residue in the potassium channel filter region controls KCNQ1 insensitivity toward scorpion toxins
por: Chen, Zongyun, et al.
Publicado: (2015)

Characterization of Kbot21 Reveals Novel Side Chain Interactions of Scorpion Toxins Inhibiting Voltage-Gated Potassium Channels
por: ElFessi-Magouri, Rym, et al.
Publicado: (2015)

Scorpion Toxins and Ion Channels: Potential Applications in Cancer Therapy
por: Dueñas-Cuellar, Rosa Amalia, et al.
Publicado: (2020)

Binding Modes of Two Scorpion Toxins to the Voltage-Gated Potassium Channel Kv1.3 Revealed from Molecular Dynamics
por: Chen, Rong, et al.
Publicado: (2014)

hERG Potassium Channel Blockage by Scorpion Toxin BmKKx2 Enhances Erythroid Differentiation of Human Leukemia Cells K562
por: Ma, Jian, et al.
Publicado: (2013)

Colombian Scorpion Centruroides margaritatus: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel
por: Beltrán-Vidal, José, et al.
Publicado: (2021)

Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
por: Oliveira, Isadora S, et al.
Publicado: (2019)

Voltage-Gated K(+)/Na(+) Channels and Scorpion Venom Toxins in Cancer
por: Díaz-García, Alexis, et al.
Publicado: (2020)

BmP02 Atypically Delays Kv4.2 Inactivation: Implication for a Unique Interaction between Scorpion Toxin and Potassium Channel
por: Wu, Bin, et al.
Publicado: (2016)

Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel
por: Hakim, Md Abdul, et al.
Publicado: (2015)

Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus
Publicado: (1989)

Overview of Scorpion Species from China and Their Toxins
por: Cao, Zhijian, et al.
Publicado: (2014)

Target-Driven Evolution of Scorpion Toxins
por: Zhang, Shangfei, et al.
Publicado: (2015)

Investigation of Binding Modes and Functional Surface of Scorpion Toxins ANEP to Sodium Channels 1.7
por: Song, Yongbo, et al.
Publicado: (2017)

Pandinus imperator scorpion venom blocks voltage-gated potassium channels in GH3 cells
por: Pappone, PA, et al.
Publicado: (1988)

Recombinant scorpion toxins: Focus on four-disulfide peptide blockers of Kv1-channels
por: Nekrasova, Oksana, et al.
Publicado: (2017)

Pain-related toxins in scorpion and spider venoms: a face to face with ion channels
por: Diochot, Sylvie
Publicado: (2021)

Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
por: Liu, Yang, et al.
Publicado: (2019)

Interaction of Scorpion α-Toxins with Cardiac Sodium Channels: Binding Properties and Enhancement of Slow Inactivation
por: Chen, Haijun, et al.
Publicado: (2001)

β-Scorpion Toxin Modifies Gating Transitions in All Four Voltage Sensors of the Sodium Channel
por: Campos, Fabiana V., et al.
Publicado: (2007)

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
por: Jiang, Daohua, et al.
Publicado: (2021)

Allosteric interactions among voltage-sensor modules of sodium channels probed by scorpion toxin modifiers
por: Gurevitz, Michael, et al.
Publicado: (2022)

Scorpion model of influenza A/H1N1: Hemagglutinin (HA) contains a scorpion toxin, binding to voltage-gated sodium Na+ channel: Na+ channel inhibitors as therapy
por: Tran, Guy Mong Ky, et al.
Publicado: (2010)

α-Scorpion Toxin Impairs a Conformational Change that Leads to Fast Inactivation of Muscle Sodium Channels
por: Campos, Fabiana V., et al.
Publicado: (2008)

Identification and Phylogenetic Analysis of Tityus pachyurus and Tityus obscurus Novel Putative Na(+)-Channel Scorpion Toxins
por: Guerrero-Vargas, Jimmy A., et al.
Publicado: (2012)

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom
por: Martin-Eauclaire, Marie-France, et al.
Publicado: (2019)

Hadrurid Scorpion Toxins: Evolutionary Conservation and Selective Pressures
por: Santibáñez-López, Carlos E., et al.
Publicado: (2019)

Rapid voltage-dependent dissociation of scorpion alpha-toxins coupled to Na channel inactivation in amphibian myelinated nerves
Publicado: (1986)

Scorpion β-toxin interference with Na(V) channel voltage sensor gives rise to excitatory and depressant modes
por: Leipold, Enrico, et al.
Publicado: (2012)

A bimodal activation mechanism underlies scorpion toxin–induced pain
por: Yang, Shilong, et al.
Publicado: (2017)

Inhibition of the Collapse of the Shaker K(+) Conductance by Specific Scorpion Toxins
por: Gómez-Lagunas, Froylan, et al.
Publicado: (2004)

Evolution Stings: The Origin and Diversification of Scorpion Toxin Peptide Scaffolds
por: Sunagar, Kartik, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_6rr1d8kdecvp4rtkgdd5grg2gb