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The potential usefulness of taurine on diabetes mellitus and its complications

Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously in millimolar concentrations in all mammalian tissues. Taurine exerts a variety of biological actions, including antioxidation, modulation of ion movement, osmoregulation, modulation of neurotransmitters, and conjugation of...

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Detalles Bibliográficos
Autores principales: Ito, Takashi, Schaffer, Stephen W., Azuma, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325402/
https://www.ncbi.nlm.nih.gov/pubmed/21437784
http://dx.doi.org/10.1007/s00726-011-0883-5
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author Ito, Takashi
Schaffer, Stephen W.
Azuma, Junichi
author_facet Ito, Takashi
Schaffer, Stephen W.
Azuma, Junichi
author_sort Ito, Takashi
collection PubMed
description Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously in millimolar concentrations in all mammalian tissues. Taurine exerts a variety of biological actions, including antioxidation, modulation of ion movement, osmoregulation, modulation of neurotransmitters, and conjugation of bile acids, which may maintain physiological homeostasis. Recently, data is accumulating that show the effectiveness of taurine against diabetes mellitus, insulin resistance and its complications, including retinopathy, nephropathy, neuropathy, atherosclerosis and cardiomyopathy, independent of hypoglycemic effect in several animal models. The useful effects appear due to the multiple actions of taurine on cellular functions. This review summarizes the beneficial effects of taurine supplementation on diabetes mellitus and the molecular mechanisms underlying its effectiveness.
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spelling pubmed-33254022012-04-20 The potential usefulness of taurine on diabetes mellitus and its complications Ito, Takashi Schaffer, Stephen W. Azuma, Junichi Amino Acids Review Article Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously in millimolar concentrations in all mammalian tissues. Taurine exerts a variety of biological actions, including antioxidation, modulation of ion movement, osmoregulation, modulation of neurotransmitters, and conjugation of bile acids, which may maintain physiological homeostasis. Recently, data is accumulating that show the effectiveness of taurine against diabetes mellitus, insulin resistance and its complications, including retinopathy, nephropathy, neuropathy, atherosclerosis and cardiomyopathy, independent of hypoglycemic effect in several animal models. The useful effects appear due to the multiple actions of taurine on cellular functions. This review summarizes the beneficial effects of taurine supplementation on diabetes mellitus and the molecular mechanisms underlying its effectiveness. Springer Vienna 2011-03-25 2012 /pmc/articles/PMC3325402/ /pubmed/21437784 http://dx.doi.org/10.1007/s00726-011-0883-5 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review Article
Ito, Takashi
Schaffer, Stephen W.
Azuma, Junichi
The potential usefulness of taurine on diabetes mellitus and its complications
title The potential usefulness of taurine on diabetes mellitus and its complications
title_full The potential usefulness of taurine on diabetes mellitus and its complications
title_fullStr The potential usefulness of taurine on diabetes mellitus and its complications
title_full_unstemmed The potential usefulness of taurine on diabetes mellitus and its complications
title_short The potential usefulness of taurine on diabetes mellitus and its complications
title_sort potential usefulness of taurine on diabetes mellitus and its complications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325402/
https://www.ncbi.nlm.nih.gov/pubmed/21437784
http://dx.doi.org/10.1007/s00726-011-0883-5
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