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The potential usefulness of taurine on diabetes mellitus and its complications
Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously in millimolar concentrations in all mammalian tissues. Taurine exerts a variety of biological actions, including antioxidation, modulation of ion movement, osmoregulation, modulation of neurotransmitters, and conjugation of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325402/ https://www.ncbi.nlm.nih.gov/pubmed/21437784 http://dx.doi.org/10.1007/s00726-011-0883-5 |
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author | Ito, Takashi Schaffer, Stephen W. Azuma, Junichi |
author_facet | Ito, Takashi Schaffer, Stephen W. Azuma, Junichi |
author_sort | Ito, Takashi |
collection | PubMed |
description | Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously in millimolar concentrations in all mammalian tissues. Taurine exerts a variety of biological actions, including antioxidation, modulation of ion movement, osmoregulation, modulation of neurotransmitters, and conjugation of bile acids, which may maintain physiological homeostasis. Recently, data is accumulating that show the effectiveness of taurine against diabetes mellitus, insulin resistance and its complications, including retinopathy, nephropathy, neuropathy, atherosclerosis and cardiomyopathy, independent of hypoglycemic effect in several animal models. The useful effects appear due to the multiple actions of taurine on cellular functions. This review summarizes the beneficial effects of taurine supplementation on diabetes mellitus and the molecular mechanisms underlying its effectiveness. |
format | Online Article Text |
id | pubmed-3325402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-33254022012-04-20 The potential usefulness of taurine on diabetes mellitus and its complications Ito, Takashi Schaffer, Stephen W. Azuma, Junichi Amino Acids Review Article Taurine (2-aminoethanesulfonic acid) is a free amino acid found ubiquitously in millimolar concentrations in all mammalian tissues. Taurine exerts a variety of biological actions, including antioxidation, modulation of ion movement, osmoregulation, modulation of neurotransmitters, and conjugation of bile acids, which may maintain physiological homeostasis. Recently, data is accumulating that show the effectiveness of taurine against diabetes mellitus, insulin resistance and its complications, including retinopathy, nephropathy, neuropathy, atherosclerosis and cardiomyopathy, independent of hypoglycemic effect in several animal models. The useful effects appear due to the multiple actions of taurine on cellular functions. This review summarizes the beneficial effects of taurine supplementation on diabetes mellitus and the molecular mechanisms underlying its effectiveness. Springer Vienna 2011-03-25 2012 /pmc/articles/PMC3325402/ /pubmed/21437784 http://dx.doi.org/10.1007/s00726-011-0883-5 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Article Ito, Takashi Schaffer, Stephen W. Azuma, Junichi The potential usefulness of taurine on diabetes mellitus and its complications |
title | The potential usefulness of taurine on diabetes mellitus and its complications |
title_full | The potential usefulness of taurine on diabetes mellitus and its complications |
title_fullStr | The potential usefulness of taurine on diabetes mellitus and its complications |
title_full_unstemmed | The potential usefulness of taurine on diabetes mellitus and its complications |
title_short | The potential usefulness of taurine on diabetes mellitus and its complications |
title_sort | potential usefulness of taurine on diabetes mellitus and its complications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325402/ https://www.ncbi.nlm.nih.gov/pubmed/21437784 http://dx.doi.org/10.1007/s00726-011-0883-5 |
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