Cargando…
Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma
PURPOSE: Recently a combination of paclitaxel and carboplatin (TC) (without an anthracycline) has begun to be used as an adjuvant or remission induction therapy, without any critical supportive evidence of its efficacy relative to a combination chemotherapy of taxane, platinum and anthracycline such...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325403/ https://www.ncbi.nlm.nih.gov/pubmed/22127553 http://dx.doi.org/10.1007/s00404-011-2154-9 |
_version_ | 1782229429627387904 |
---|---|
author | Fujiwara, Kazuko Egawa-Takata, Tomomi Ueda, Yutaka Kimura, Toshihiro Yoshino, Kiyoshi Fujita, Masami Miyatake, Takashi Ohta, Yukinobu Kamiura, Shoji Enomoto, Takayuki Kimura, Tadashi |
author_facet | Fujiwara, Kazuko Egawa-Takata, Tomomi Ueda, Yutaka Kimura, Toshihiro Yoshino, Kiyoshi Fujita, Masami Miyatake, Takashi Ohta, Yukinobu Kamiura, Shoji Enomoto, Takayuki Kimura, Tadashi |
author_sort | Fujiwara, Kazuko |
collection | PubMed |
description | PURPOSE: Recently a combination of paclitaxel and carboplatin (TC) (without an anthracycline) has begun to be used as an adjuvant or remission induction therapy, without any critical supportive evidence of its efficacy relative to a combination chemotherapy of taxane, platinum and anthracycline such as TEC (paclitaxel, epirubicin and carboplatin). The aim of our present study was to conduct the required clinical evaluations of the relative effectiveness of TC compared to TEC. METHODS: A retrospective comparison between the efficacy of TEC and TC regimens used for endometrial carcinoma at the Osaka University Hospital and the Osaka Medical Center for Cancer and Cardiovascular Diseases in Osaka, Japan, respectively, from 1999 to 2009 was performed. The clinical characteristics of the patients who received either TEC or TC were not significantly different, and TEC and TC therapies were initiated based on similar indications for chemotherapy. TEC regimen was paclitaxel (150 mg/m(2)), epirubicin (50 mg/m(2)) and carboplatin (AUC 4). TC regimen consisted of paclitaxel (175 mg/m(2)) and carboplatin (AUC 5). RESULTS: TEC was demonstrated to provide significantly better survival than TC as an adjuvant therapy for resected Stage III/IV diseases (p = 0.017 for progression-free survival and p = 0.014 for overall survival, by the log-rank test). However, in recurrent or more advanced cases, TC and TEC demonstrated similar effects on survival (p = 0.55 for progression-free survival and p = 0.63 for overall survival). CONCLUSIONS: TEC should be offered as an adjuvant therapy to Stage III/IV patients. TC may be considered for recurrent or unresectable cases as a remission induction therapy. |
format | Online Article Text |
id | pubmed-3325403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33254032012-04-20 Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma Fujiwara, Kazuko Egawa-Takata, Tomomi Ueda, Yutaka Kimura, Toshihiro Yoshino, Kiyoshi Fujita, Masami Miyatake, Takashi Ohta, Yukinobu Kamiura, Shoji Enomoto, Takayuki Kimura, Tadashi Arch Gynecol Obstet Gynecologic Oncology PURPOSE: Recently a combination of paclitaxel and carboplatin (TC) (without an anthracycline) has begun to be used as an adjuvant or remission induction therapy, without any critical supportive evidence of its efficacy relative to a combination chemotherapy of taxane, platinum and anthracycline such as TEC (paclitaxel, epirubicin and carboplatin). The aim of our present study was to conduct the required clinical evaluations of the relative effectiveness of TC compared to TEC. METHODS: A retrospective comparison between the efficacy of TEC and TC regimens used for endometrial carcinoma at the Osaka University Hospital and the Osaka Medical Center for Cancer and Cardiovascular Diseases in Osaka, Japan, respectively, from 1999 to 2009 was performed. The clinical characteristics of the patients who received either TEC or TC were not significantly different, and TEC and TC therapies were initiated based on similar indications for chemotherapy. TEC regimen was paclitaxel (150 mg/m(2)), epirubicin (50 mg/m(2)) and carboplatin (AUC 4). TC regimen consisted of paclitaxel (175 mg/m(2)) and carboplatin (AUC 5). RESULTS: TEC was demonstrated to provide significantly better survival than TC as an adjuvant therapy for resected Stage III/IV diseases (p = 0.017 for progression-free survival and p = 0.014 for overall survival, by the log-rank test). However, in recurrent or more advanced cases, TC and TEC demonstrated similar effects on survival (p = 0.55 for progression-free survival and p = 0.63 for overall survival). CONCLUSIONS: TEC should be offered as an adjuvant therapy to Stage III/IV patients. TC may be considered for recurrent or unresectable cases as a remission induction therapy. Springer-Verlag 2011-11-30 2012 /pmc/articles/PMC3325403/ /pubmed/22127553 http://dx.doi.org/10.1007/s00404-011-2154-9 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Gynecologic Oncology Fujiwara, Kazuko Egawa-Takata, Tomomi Ueda, Yutaka Kimura, Toshihiro Yoshino, Kiyoshi Fujita, Masami Miyatake, Takashi Ohta, Yukinobu Kamiura, Shoji Enomoto, Takayuki Kimura, Tadashi Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma |
title | Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma |
title_full | Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma |
title_fullStr | Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma |
title_full_unstemmed | Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma |
title_short | Investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma |
title_sort | investigating the relative efficacies of combination chemotherapy of paclitaxel/carboplatin, with or without anthracycline, for endometrial carcinoma |
topic | Gynecologic Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325403/ https://www.ncbi.nlm.nih.gov/pubmed/22127553 http://dx.doi.org/10.1007/s00404-011-2154-9 |
work_keys_str_mv | AT fujiwarakazuko investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT egawatakatatomomi investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT uedayutaka investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT kimuratoshihiro investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT yoshinokiyoshi investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT fujitamasami investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT miyataketakashi investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT ohtayukinobu investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT kamiurashoji investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT enomototakayuki investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma AT kimuratadashi investigatingtherelativeefficaciesofcombinationchemotherapyofpaclitaxelcarboplatinwithorwithoutanthracyclineforendometrialcarcinoma |