Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets

Current genome-wide association studies (GWAS) use commercial genotyping microarrays that can assay over a million single nucleotide polymorphisms (SNPs). The number of SNPs is further boosted by advanced statistical genotype-imputation algorithms and large SNP databases for reference human populati...

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Detalles Bibliográficos
Autores principales: Li, Miao-Xin, Yeung, Juilian M. Y., Cherny, Stacey S., Sham, Pak C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325408/
https://www.ncbi.nlm.nih.gov/pubmed/22143225
http://dx.doi.org/10.1007/s00439-011-1118-2

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