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Pegylated Interferon-Associated Severe Retinopathy in a Patient with Chronic Hepatitis

This paper reports a case of pegylated interferon-associated retinopathy in a patient with chronic hepatitis C. A 32-year-old female with chronic hepatitis C undergoing pegylated interferon and ribavirin combination therapy complained of visual blurring. Features of interferon-associated retinopathy...

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Detalles Bibliográficos
Autores principales: Kang, Hee Young, Shin, Min Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Ophthalmological Society 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325622/
https://www.ncbi.nlm.nih.gov/pubmed/22511844
http://dx.doi.org/10.3341/kjo.2012.26.2.147
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author Kang, Hee Young
Shin, Min Chul
author_facet Kang, Hee Young
Shin, Min Chul
author_sort Kang, Hee Young
collection PubMed
description This paper reports a case of pegylated interferon-associated retinopathy in a patient with chronic hepatitis C. A 32-year-old female with chronic hepatitis C undergoing pegylated interferon and ribavirin combination therapy complained of visual blurring. Features of interferon-associated retinopathy, including ocular complications such as cotton wool spots, retinal hemorrhages, macular edema, and branch retinal vein occlusion, were found in the fundus of both of her eyes. Pegylated interferon combination therapy was stopped, and the retinopathy of the patient was treated with intravitreal bevacizumab injections and panretinal photocoagulations. This case shows that pharmacokinetically improved pegylated interferon has ocular complications for patients with chronic hepatitis C. Accordingly, patients undergoing pegylated interferon treatment for hepatitis C need regular eye examinations for protection of their vision.
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spelling pubmed-33256222012-04-17 Pegylated Interferon-Associated Severe Retinopathy in a Patient with Chronic Hepatitis Kang, Hee Young Shin, Min Chul Korean J Ophthalmol Case Report This paper reports a case of pegylated interferon-associated retinopathy in a patient with chronic hepatitis C. A 32-year-old female with chronic hepatitis C undergoing pegylated interferon and ribavirin combination therapy complained of visual blurring. Features of interferon-associated retinopathy, including ocular complications such as cotton wool spots, retinal hemorrhages, macular edema, and branch retinal vein occlusion, were found in the fundus of both of her eyes. Pegylated interferon combination therapy was stopped, and the retinopathy of the patient was treated with intravitreal bevacizumab injections and panretinal photocoagulations. This case shows that pharmacokinetically improved pegylated interferon has ocular complications for patients with chronic hepatitis C. Accordingly, patients undergoing pegylated interferon treatment for hepatitis C need regular eye examinations for protection of their vision. The Korean Ophthalmological Society 2012-04 2012-03-22 /pmc/articles/PMC3325622/ /pubmed/22511844 http://dx.doi.org/10.3341/kjo.2012.26.2.147 Text en © 2012 The Korean Ophthalmological Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kang, Hee Young
Shin, Min Chul
Pegylated Interferon-Associated Severe Retinopathy in a Patient with Chronic Hepatitis
title Pegylated Interferon-Associated Severe Retinopathy in a Patient with Chronic Hepatitis
title_full Pegylated Interferon-Associated Severe Retinopathy in a Patient with Chronic Hepatitis
title_fullStr Pegylated Interferon-Associated Severe Retinopathy in a Patient with Chronic Hepatitis
title_full_unstemmed Pegylated Interferon-Associated Severe Retinopathy in a Patient with Chronic Hepatitis
title_short Pegylated Interferon-Associated Severe Retinopathy in a Patient with Chronic Hepatitis
title_sort pegylated interferon-associated severe retinopathy in a patient with chronic hepatitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325622/
https://www.ncbi.nlm.nih.gov/pubmed/22511844
http://dx.doi.org/10.3341/kjo.2012.26.2.147
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