New Array Approaches to Explore Single Cells Genomes

Microarray analysis enables the genome-wide detection of copy number variations and the investigation of chromosomal instability. Whereas array techniques have been well established for the analysis of unamplified DNA derived from many cells, it has been more challenging to enable the accurate analy...

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Detalles Bibliográficos
Autores principales: Vanneste, Evelyne, Bittman, Lilach, Van der Aa, Niels, Voet, Thierry, Vermeesch, Joris Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325760/
https://www.ncbi.nlm.nih.gov/pubmed/22509179
http://dx.doi.org/10.3389/fgene.2012.00044
Descripción
Sumario:Microarray analysis enables the genome-wide detection of copy number variations and the investigation of chromosomal instability. Whereas array techniques have been well established for the analysis of unamplified DNA derived from many cells, it has been more challenging to enable the accurate analysis of single cell genomes. In this review, we provide an overview of single cell DNA amplification techniques, the different array approaches, and discuss their potential applications to study human embryos.

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