New Array Approaches to Explore Single Cells Genomes

Microarray analysis enables the genome-wide detection of copy number variations and the investigation of chromosomal instability. Whereas array techniques have been well established for the analysis of unamplified DNA derived from many cells, it has been more challenging to enable the accurate analy...

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Autores principales: Vanneste, Evelyne, Bittman, Lilach, Van der Aa, Niels, Voet, Thierry, Vermeesch, Joris Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325760/
https://www.ncbi.nlm.nih.gov/pubmed/22509179
http://dx.doi.org/10.3389/fgene.2012.00044
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author Vanneste, Evelyne
Bittman, Lilach
Van der Aa, Niels
Voet, Thierry
Vermeesch, Joris Robert
author_facet Vanneste, Evelyne
Bittman, Lilach
Van der Aa, Niels
Voet, Thierry
Vermeesch, Joris Robert
author_sort Vanneste, Evelyne
collection PubMed
description Microarray analysis enables the genome-wide detection of copy number variations and the investigation of chromosomal instability. Whereas array techniques have been well established for the analysis of unamplified DNA derived from many cells, it has been more challenging to enable the accurate analysis of single cell genomes. In this review, we provide an overview of single cell DNA amplification techniques, the different array approaches, and discuss their potential applications to study human embryos.
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spelling pubmed-33257602012-04-16 New Array Approaches to Explore Single Cells Genomes Vanneste, Evelyne Bittman, Lilach Van der Aa, Niels Voet, Thierry Vermeesch, Joris Robert Front Genet Genetics Microarray analysis enables the genome-wide detection of copy number variations and the investigation of chromosomal instability. Whereas array techniques have been well established for the analysis of unamplified DNA derived from many cells, it has been more challenging to enable the accurate analysis of single cell genomes. In this review, we provide an overview of single cell DNA amplification techniques, the different array approaches, and discuss their potential applications to study human embryos. Frontiers Research Foundation 2012-03-27 /pmc/articles/PMC3325760/ /pubmed/22509179 http://dx.doi.org/10.3389/fgene.2012.00044 Text en Copyright © 2012 Vanneste, Bittman, Van der Aa, Voet and Vermeesch. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Genetics
Vanneste, Evelyne
Bittman, Lilach
Van der Aa, Niels
Voet, Thierry
Vermeesch, Joris Robert
New Array Approaches to Explore Single Cells Genomes
title New Array Approaches to Explore Single Cells Genomes
title_full New Array Approaches to Explore Single Cells Genomes
title_fullStr New Array Approaches to Explore Single Cells Genomes
title_full_unstemmed New Array Approaches to Explore Single Cells Genomes
title_short New Array Approaches to Explore Single Cells Genomes
title_sort new array approaches to explore single cells genomes
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325760/
https://www.ncbi.nlm.nih.gov/pubmed/22509179
http://dx.doi.org/10.3389/fgene.2012.00044
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