Susceptibility testing of Atopobium vaginae for dequalinium chloride

BACKGROUND: Atopobium vaginae and Gardnerella vaginalis are major markers for bacterial vaginosis. We aimed to determine the MIC and MBC range of the broad-spectrum anti-infective and antiseptic dequalinium chloride for 28 strains, belonging to 4 species of the genus Atopobium, i.e. A. vaginae, A. m...

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Autores principales: Lopes dos Santos Santiago, Guido, Grob, Philipp, Verstraelen, Hans, Waser, Florian, Vaneechoutte, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325845/
https://www.ncbi.nlm.nih.gov/pubmed/22429611
http://dx.doi.org/10.1186/1756-0500-5-151
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author Lopes dos Santos Santiago, Guido
Grob, Philipp
Verstraelen, Hans
Waser, Florian
Vaneechoutte, Mario
author_facet Lopes dos Santos Santiago, Guido
Grob, Philipp
Verstraelen, Hans
Waser, Florian
Vaneechoutte, Mario
author_sort Lopes dos Santos Santiago, Guido
collection PubMed
description BACKGROUND: Atopobium vaginae and Gardnerella vaginalis are major markers for bacterial vaginosis. We aimed to determine the MIC and MBC range of the broad-spectrum anti-infective and antiseptic dequalinium chloride for 28 strains, belonging to 4 species of the genus Atopobium, i.e. A. vaginae, A. minutum, A. rimae and A. parvulum. METHODS: The MIC was determined with a broth microdilution assay. RESULTS: The MIC and MBC for Atopobium spp. for dequalinium chloride ranged between < 0.0625 and 2 μg/ml. CONCLUSIONS: This study demonstrated that dequalinium chloride inhibits and kills clinical isolates of A. vaginae at concentrations similar to those of clindamycin and lower than those of metronidazole.
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spelling pubmed-33258452012-04-14 Susceptibility testing of Atopobium vaginae for dequalinium chloride Lopes dos Santos Santiago, Guido Grob, Philipp Verstraelen, Hans Waser, Florian Vaneechoutte, Mario BMC Res Notes Research Article BACKGROUND: Atopobium vaginae and Gardnerella vaginalis are major markers for bacterial vaginosis. We aimed to determine the MIC and MBC range of the broad-spectrum anti-infective and antiseptic dequalinium chloride for 28 strains, belonging to 4 species of the genus Atopobium, i.e. A. vaginae, A. minutum, A. rimae and A. parvulum. METHODS: The MIC was determined with a broth microdilution assay. RESULTS: The MIC and MBC for Atopobium spp. for dequalinium chloride ranged between < 0.0625 and 2 μg/ml. CONCLUSIONS: This study demonstrated that dequalinium chloride inhibits and kills clinical isolates of A. vaginae at concentrations similar to those of clindamycin and lower than those of metronidazole. BioMed Central 2012-03-19 /pmc/articles/PMC3325845/ /pubmed/22429611 http://dx.doi.org/10.1186/1756-0500-5-151 Text en Copyright ©2012 Santiago et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lopes dos Santos Santiago, Guido
Grob, Philipp
Verstraelen, Hans
Waser, Florian
Vaneechoutte, Mario
Susceptibility testing of Atopobium vaginae for dequalinium chloride
title Susceptibility testing of Atopobium vaginae for dequalinium chloride
title_full Susceptibility testing of Atopobium vaginae for dequalinium chloride
title_fullStr Susceptibility testing of Atopobium vaginae for dequalinium chloride
title_full_unstemmed Susceptibility testing of Atopobium vaginae for dequalinium chloride
title_short Susceptibility testing of Atopobium vaginae for dequalinium chloride
title_sort susceptibility testing of atopobium vaginae for dequalinium chloride
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325845/
https://www.ncbi.nlm.nih.gov/pubmed/22429611
http://dx.doi.org/10.1186/1756-0500-5-151
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