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Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials

Observational studies have shown that low serum levels of vitamin D have been associated with an atherogenic lipid profile. However, the intervention studies gave divergent results. We conducted a meta-analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation o...

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Autores principales: Wang, Hao, Xia, Ning, Yang, Yang, Peng, Dao-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325888/
https://www.ncbi.nlm.nih.gov/pubmed/22433171
http://dx.doi.org/10.1186/1476-511X-11-42
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author Wang, Hao
Xia, Ning
Yang, Yang
Peng, Dao-Quan
author_facet Wang, Hao
Xia, Ning
Yang, Yang
Peng, Dao-Quan
author_sort Wang, Hao
collection PubMed
description Observational studies have shown that low serum levels of vitamin D have been associated with an atherogenic lipid profile. However, the intervention studies gave divergent results. We conducted a meta-analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation on blood lipids. A systematic literature search was conducted via MEDLINE, Cochrane library, and EMBASE for randomized controlled clinical trials assessing the effects of vitamin D supplementation on lipids. The mean change in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) from baseline was treated as a continuous variable. In all, 12 clinical trials consisting of 1346 participants were included in the analysis. The pooled estimate of effect for vitamin D supplementation on LDL-C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl). No statistically significant effects for vitamin D supplementation were observed for TC, HDL-C and TG (differences in means were 1.52 mg/dl (-1.42 to 4.46 mg/dl), -0.14 mg/dl (-0.99 to 0.71 mg/dl) and -1.92 mg/dl (-7.72 to 3.88 mg/dl) respectively). The lipid modulating effects of vitamin D supplementation should be further investigated though large-scale, randomized trials with adequate doses which can effectively elevated the active form of vitamin D in plasma and with proper population which has hyperlipemia as an inclusion criterion.
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spelling pubmed-33258882012-04-16 Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials Wang, Hao Xia, Ning Yang, Yang Peng, Dao-Quan Lipids Health Dis Review Observational studies have shown that low serum levels of vitamin D have been associated with an atherogenic lipid profile. However, the intervention studies gave divergent results. We conducted a meta-analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation on blood lipids. A systematic literature search was conducted via MEDLINE, Cochrane library, and EMBASE for randomized controlled clinical trials assessing the effects of vitamin D supplementation on lipids. The mean change in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) from baseline was treated as a continuous variable. In all, 12 clinical trials consisting of 1346 participants were included in the analysis. The pooled estimate of effect for vitamin D supplementation on LDL-C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl). No statistically significant effects for vitamin D supplementation were observed for TC, HDL-C and TG (differences in means were 1.52 mg/dl (-1.42 to 4.46 mg/dl), -0.14 mg/dl (-0.99 to 0.71 mg/dl) and -1.92 mg/dl (-7.72 to 3.88 mg/dl) respectively). The lipid modulating effects of vitamin D supplementation should be further investigated though large-scale, randomized trials with adequate doses which can effectively elevated the active form of vitamin D in plasma and with proper population which has hyperlipemia as an inclusion criterion. BioMed Central 2012-03-20 /pmc/articles/PMC3325888/ /pubmed/22433171 http://dx.doi.org/10.1186/1476-511X-11-42 Text en Copyright ©2012 Wang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wang, Hao
Xia, Ning
Yang, Yang
Peng, Dao-Quan
Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials
title Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials
title_full Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials
title_fullStr Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials
title_full_unstemmed Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials
title_short Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials
title_sort influence of vitamin d supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325888/
https://www.ncbi.nlm.nih.gov/pubmed/22433171
http://dx.doi.org/10.1186/1476-511X-11-42
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