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Premature Senescence and Increased TGFβ Signaling in the Absence of Tgif1

Transforming growth factor β (TGFβ) signaling regulates cell cycle progression in several cell types, primarily by inducing a G1 cell cycle arrest. Tgif1 is a transcriptional corepressor that limits TGFβ responsive gene expression. Here we demonstrate that primary mouse embryo fibroblasts (MEFs) lac...

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Detalles Bibliográficos
Autores principales:	Zerlanko, Brad J., Bartholin, Laurent, Melhuish, Tiffany A., Wotton, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325954/ https://www.ncbi.nlm.nih.gov/pubmed/22514746 http://dx.doi.org/10.1371/journal.pone.0035460

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