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Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern
The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain. One key feature of this bilateral nucleus is the presence of left-right differences in size, cytoarchitecture, co...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325962/ https://www.ncbi.nlm.nih.gov/pubmed/22514727 http://dx.doi.org/10.1371/journal.pone.0035329 |
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author | Villalón, Aldo Sepúlveda, Mauricio Guerrero, Néstor Meynard, Margarita M. Palma, Karina Concha, Miguel L. |
author_facet | Villalón, Aldo Sepúlveda, Mauricio Guerrero, Néstor Meynard, Margarita M. Palma, Karina Concha, Miguel L. |
author_sort | Villalón, Aldo |
collection | PubMed |
description | The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain. One key feature of this bilateral nucleus is the presence of left-right differences in size, cytoarchitecture, connectivity, neurochemistry and/or gene expression. In teleosts, habenular asymmetry has been associated with preferential innervation of left-right habenular efferents into dorso-ventral domains of the midbrain interpeduncular nucleus (IPN). However, the degree of conservation of this trait and its relation to the structural asymmetries of the Hb are currently unknown. To address these questions, we performed the first systematic comparative analysis of structural and connectional asymmetries of the Hb in teleosts. We found striking inter-species variability in the overall shape and cytoarchitecture of the Hb, and in the frequency, strength and to a lesser degree, laterality of habenular volume at the population level. Directional asymmetry of the Hb was either to the left in D. rerio, E. bicolor, O. latipes, P. reticulata, B. splendens, or to the right in F. gardneri females. In contrast, asymmetry was absent in P. scalare and F. gardneri males at the population level, although in these species the Hb displayed volumetric asymmetries at the individual level. Inter-species variability was more pronounced across orders than within a single order, and coexisted with an overall conserved laterotopic representation of left-right habenular efferents into dorso-ventral domains of the IPN. These results suggest that the circuit design involving the Hb of teleosts promotes structural flexibility depending on developmental, cognitive and/or behavioural pressures, without affecting the main midbrain connectivity output, thus unveiling a key conserved role of this connectivity trait in the function of the circuit. We propose that ontogenic plasticity in habenular morphogenesis underlies the observed inter-species variations in habenular asymmetric morphology. |
format | Online Article Text |
id | pubmed-3325962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33259622012-04-18 Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern Villalón, Aldo Sepúlveda, Mauricio Guerrero, Néstor Meynard, Margarita M. Palma, Karina Concha, Miguel L. PLoS One Research Article The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain. One key feature of this bilateral nucleus is the presence of left-right differences in size, cytoarchitecture, connectivity, neurochemistry and/or gene expression. In teleosts, habenular asymmetry has been associated with preferential innervation of left-right habenular efferents into dorso-ventral domains of the midbrain interpeduncular nucleus (IPN). However, the degree of conservation of this trait and its relation to the structural asymmetries of the Hb are currently unknown. To address these questions, we performed the first systematic comparative analysis of structural and connectional asymmetries of the Hb in teleosts. We found striking inter-species variability in the overall shape and cytoarchitecture of the Hb, and in the frequency, strength and to a lesser degree, laterality of habenular volume at the population level. Directional asymmetry of the Hb was either to the left in D. rerio, E. bicolor, O. latipes, P. reticulata, B. splendens, or to the right in F. gardneri females. In contrast, asymmetry was absent in P. scalare and F. gardneri males at the population level, although in these species the Hb displayed volumetric asymmetries at the individual level. Inter-species variability was more pronounced across orders than within a single order, and coexisted with an overall conserved laterotopic representation of left-right habenular efferents into dorso-ventral domains of the IPN. These results suggest that the circuit design involving the Hb of teleosts promotes structural flexibility depending on developmental, cognitive and/or behavioural pressures, without affecting the main midbrain connectivity output, thus unveiling a key conserved role of this connectivity trait in the function of the circuit. We propose that ontogenic plasticity in habenular morphogenesis underlies the observed inter-species variations in habenular asymmetric morphology. Public Library of Science 2012-04-13 /pmc/articles/PMC3325962/ /pubmed/22514727 http://dx.doi.org/10.1371/journal.pone.0035329 Text en Villalón et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Villalón, Aldo Sepúlveda, Mauricio Guerrero, Néstor Meynard, Margarita M. Palma, Karina Concha, Miguel L. Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern |
title | Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern |
title_full | Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern |
title_fullStr | Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern |
title_full_unstemmed | Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern |
title_short | Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern |
title_sort | evolutionary plasticity of habenular asymmetry with a conserved efferent connectivity pattern |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325962/ https://www.ncbi.nlm.nih.gov/pubmed/22514727 http://dx.doi.org/10.1371/journal.pone.0035329 |
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