Proteasome Inhibition Is Partially Effective in Attenuating Pre-Existing Immunity against Recombinant Adeno-Associated Viral Vectors

Pre-existing immunity against adeno-associated virus (AAV) remains a major challenge facing the clinical use of systemic administration of recombinant AAV vectors for the treatment of genetic and acquired diseases using gene therapy. In this study, we evaluated the potential of bortezomib (marketed...

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Detalles Bibliográficos
Autores principales: Karman, Jozsef, Gumlaw, Nathan K., Zhang, Jinhua, Jiang, Ji-Lei, Cheng, Seng H., Zhu, Yunxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326043/
https://www.ncbi.nlm.nih.gov/pubmed/22514654
http://dx.doi.org/10.1371/journal.pone.0034684

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