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Differential Effects of UCHL1 Modulation on Alpha-Synuclein in PD-Like Models of Alpha-Synucleinopathy

Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by genetic and environmental factors. Abnormal accumulation and aggregation of alpha-synuclein (a-syn) within neurons, and mutations in the a-syn and UCH-L1 genes have been shown to play a role in the pathogenesis of PD...

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Detalles Bibliográficos
Autores principales:	Cartier, Anna E., Ubhi, Kiren, Spencer, Brian, Vazquez-Roque, Ruben A., Kosberg, Kori Ann, Fourgeaud, Lawrence, Kanayson, Priya, Patrick, Christina, Rockenstein, Edward, Patrick, Gentry N., Masliah, Eliezer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326048/ https://www.ncbi.nlm.nih.gov/pubmed/22514658 http://dx.doi.org/10.1371/journal.pone.0034713

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