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Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

Huntington's disease is caused by expression of a mutant form of Huntingtin protein containing an expanded polyglutamine repeat. One possible treatment for Huntington's disease may be to reduce expression of mutant Huntingtin in the brain via RNA interference. Unless the therapeutic molecu...

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Detalles Bibliográficos
Autores principales:	Grondin, Richard, Kaytor, Michael D., Ai, Yi, Nelson, Peter T., Thakker, Deepak R., Heisel, Jennifer, Weatherspoon, Marcy R., Blum, Janelle L., Burright, Eric N., Zhang, Zhiming, Kaemmerer, William F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Occasional Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326247/ https://www.ncbi.nlm.nih.gov/pubmed/22252996 http://dx.doi.org/10.1093/brain/awr333

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