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Suppression of protein aggregation by chaperone modification of high molecular weight complexes

Protein misfolding and aggregation are associated with many neurodegenerative diseases, including Huntington’s disease. The cellular machinery for maintaining proteostasis includes molecular chaperones that facilitate protein folding and reduce proteotoxicity. Increasing the protein folding capacity...

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Detalles Bibliográficos
Autores principales:	Labbadia, John, Novoselov, Sergey S., Bett, John S., Weiss, Andreas, Paganetti, Paolo, Bates, Gillian P., Cheetham, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326252/ https://www.ncbi.nlm.nih.gov/pubmed/22396390 http://dx.doi.org/10.1093/brain/aws022

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