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Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

Ethionamide is an antituberculous drug for the treatment of multidrug-resistant Mycobacterium tuberculosis. This antibiotic requires activation by the monooxygenase EthA to exert its activity. Production of EthA is controlled by the transcriptional repressor EthR, a member of the TetR family. The se...

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Detalles Bibliográficos
Autores principales:	Carette, Xavier, Blondiaux, Nicolas, Willery, Eve, Hoos, Sylviane, Lecat-Guillet, Nathalie, Lens, Zoé, Wohlkönig, Alexandre, Wintjens, René, Soror, Sameh H., Frénois, Frédéric, Dirié, Bertrand, Villeret, Vincent, England, Patrick, Lippens, Guy, Deprez, Benoit, Locht, Camille, Willand, Nicolas, Baulard, Alain R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326297/ https://www.ncbi.nlm.nih.gov/pubmed/22156370 http://dx.doi.org/10.1093/nar/gkr1113

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