ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the GroEL Chaperonin

The chaperonin GroEL assists the folding of nascent or stress-denatured polypeptides by actions of binding and encapsulation. ATP binding initiates a series of conformational changes triggering the association of the cochaperonin GroES, followed by further large movements that eject the substrate po...

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Detalles Bibliográficos
Autores principales: Clare, Daniel K., Vasishtan, Daven, Stagg, Scott, Quispe, Joel, Farr, George W., Topf, Maya, Horwich, Arthur L., Saibil, Helen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326522/
https://www.ncbi.nlm.nih.gov/pubmed/22445172
http://dx.doi.org/10.1016/j.cell.2012.02.047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326522/
https://www.ncbi.nlm.nih.gov/pubmed/22445172
http://dx.doi.org/10.1016/j.cell.2012.02.047

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