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N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis

The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative cata...

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Detalles Bibliográficos
Autores principales: De Vreese, Rob, D’hooghe, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326616/
https://www.ncbi.nlm.nih.gov/pubmed/22509208
http://dx.doi.org/10.3762/bjoc.8.43
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author De Vreese, Rob
D’hooghe, Matthias
author_facet De Vreese, Rob
D’hooghe, Matthias
author_sort De Vreese, Rob
collection PubMed
description The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable scaffolds in heterocyclic chemistry. This Commentary will briefly highlight the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis as a new and powerful methodology in organic chemistry.
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spelling pubmed-33266162012-04-16 N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis De Vreese, Rob D’hooghe, Matthias Beilstein J Org Chem Commentary The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable scaffolds in heterocyclic chemistry. This Commentary will briefly highlight the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis as a new and powerful methodology in organic chemistry. Beilstein-Institut 2012-03-14 /pmc/articles/PMC3326616/ /pubmed/22509208 http://dx.doi.org/10.3762/bjoc.8.43 Text en Copyright © 2012, De Vreese and D’hooghe https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Commentary
De Vreese, Rob
D’hooghe, Matthias
N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis
title N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis
title_full N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis
title_fullStr N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis
title_full_unstemmed N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis
title_short N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis
title_sort n-heterocyclic carbene/brønsted acid cooperative catalysis as a powerful tool in organic synthesis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326616/
https://www.ncbi.nlm.nih.gov/pubmed/22509208
http://dx.doi.org/10.3762/bjoc.8.43
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