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N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis
The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative cata...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Beilstein-Institut
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326616/ https://www.ncbi.nlm.nih.gov/pubmed/22509208 http://dx.doi.org/10.3762/bjoc.8.43 |
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author | De Vreese, Rob D’hooghe, Matthias |
author_facet | De Vreese, Rob D’hooghe, Matthias |
author_sort | De Vreese, Rob |
collection | PubMed |
description | The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable scaffolds in heterocyclic chemistry. This Commentary will briefly highlight the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis as a new and powerful methodology in organic chemistry. |
format | Online Article Text |
id | pubmed-3326616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-33266162012-04-16 N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis De Vreese, Rob D’hooghe, Matthias Beilstein J Org Chem Commentary The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable scaffolds in heterocyclic chemistry. This Commentary will briefly highlight the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis as a new and powerful methodology in organic chemistry. Beilstein-Institut 2012-03-14 /pmc/articles/PMC3326616/ /pubmed/22509208 http://dx.doi.org/10.3762/bjoc.8.43 Text en Copyright © 2012, De Vreese and D’hooghe https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Commentary De Vreese, Rob D’hooghe, Matthias N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis |
title | N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis |
title_full | N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis |
title_fullStr | N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis |
title_full_unstemmed | N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis |
title_short | N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis |
title_sort | n-heterocyclic carbene/brønsted acid cooperative catalysis as a powerful tool in organic synthesis |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326616/ https://www.ncbi.nlm.nih.gov/pubmed/22509208 http://dx.doi.org/10.3762/bjoc.8.43 |
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