Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

Oncogenic fusion proteins, such as EWS-FLI1, are excellent therapeutic targets as they are only located within the tumor. However, there are currently no agents targeted toward transcription factors, which are often considered to be ‘undruggable.’ A considerable body of evidence is accruing that ref...

Descripción completa

Detalles Bibliográficos
Autores principales: Barber-Rotenberg, Julie S., Selvanathan, Saravana P., Kong, Yali, Erkizan, Hayriye V., Snyder, Tara M., Hong, S. Peter, Kobs, Christina L., South, Natalie L., Summer, Steven, Monroe, Philip J., Chruszcz, Maksymilian, Dobrev, Veselin, Tosso, Perrer N., Scher, Lauren J., Minor, Wladek, Brown, Milton L., Metallo, Steven J., Üren, Aykut, Toretsky, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326647/
https://www.ncbi.nlm.nih.gov/pubmed/22383402

Ejemplares similares

Ejemplares similares