The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems

Nanodiamonds (NDs), as a new member of the carbon nanoparticles family, have attracted more and more attention in biomedicine recently due to their excellent physical and chemical properties. This paper summarizes the main results from the in vitro and in vivo safety assessments of NDs and reports t...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Ying, Li, Jing, Li, Wenxin, Zhang, Yu, Yang, Xiafeng, Chen, Nan, Sun, Yanhong, Zhao, Yun, Fan, Chunhai, Huang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326739/
https://www.ncbi.nlm.nih.gov/pubmed/22509196
http://dx.doi.org/10.7150/thno.3627
_version_ 1782229559146446848
author Zhu, Ying
Li, Jing
Li, Wenxin
Zhang, Yu
Yang, Xiafeng
Chen, Nan
Sun, Yanhong
Zhao, Yun
Fan, Chunhai
Huang, Qing
author_facet Zhu, Ying
Li, Jing
Li, Wenxin
Zhang, Yu
Yang, Xiafeng
Chen, Nan
Sun, Yanhong
Zhao, Yun
Fan, Chunhai
Huang, Qing
author_sort Zhu, Ying
collection PubMed
description Nanodiamonds (NDs), as a new member of the carbon nanoparticles family, have attracted more and more attention in biomedicine recently due to their excellent physical and chemical properties. This paper summarizes the main results from the in vitro and in vivo safety assessments of NDs and reports the application of NDs in the development of drug delivery systems. In view of the NDs' characteristics of easy formation of a porous cluster structure in solution, an adsorption model for a variety of functional molecules on the ND clusters is proposed, which provides new ideas for developing a novel smart drug with various features such as sustained-release, targeting, and fluorescence imaging.
format Online
Article
Text
id pubmed-3326739
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-33267392012-04-16 The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems Zhu, Ying Li, Jing Li, Wenxin Zhang, Yu Yang, Xiafeng Chen, Nan Sun, Yanhong Zhao, Yun Fan, Chunhai Huang, Qing Theranostics Review Nanodiamonds (NDs), as a new member of the carbon nanoparticles family, have attracted more and more attention in biomedicine recently due to their excellent physical and chemical properties. This paper summarizes the main results from the in vitro and in vivo safety assessments of NDs and reports the application of NDs in the development of drug delivery systems. In view of the NDs' characteristics of easy formation of a porous cluster structure in solution, an adsorption model for a variety of functional molecules on the ND clusters is proposed, which provides new ideas for developing a novel smart drug with various features such as sustained-release, targeting, and fluorescence imaging. Ivyspring International Publisher 2012-03-07 /pmc/articles/PMC3326739/ /pubmed/22509196 http://dx.doi.org/10.7150/thno.3627 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Zhu, Ying
Li, Jing
Li, Wenxin
Zhang, Yu
Yang, Xiafeng
Chen, Nan
Sun, Yanhong
Zhao, Yun
Fan, Chunhai
Huang, Qing
The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems
title The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems
title_full The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems
title_fullStr The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems
title_full_unstemmed The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems
title_short The Biocompatibility of Nanodiamonds and Their Application in Drug Delivery Systems
title_sort biocompatibility of nanodiamonds and their application in drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326739/
https://www.ncbi.nlm.nih.gov/pubmed/22509196
http://dx.doi.org/10.7150/thno.3627
work_keys_str_mv AT zhuying thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT lijing thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT liwenxin thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT zhangyu thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT yangxiafeng thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT chennan thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT sunyanhong thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT zhaoyun thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT fanchunhai thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT huangqing thebiocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT zhuying biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT lijing biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT liwenxin biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT zhangyu biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT yangxiafeng biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT chennan biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT sunyanhong biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT zhaoyun biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT fanchunhai biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems
AT huangqing biocompatibilityofnanodiamondsandtheirapplicationindrugdeliverysystems

Ejemplares similares