In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.

OBJECTIVE: This study was undertaken to study in vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. MATERIALS AND MATHODS: Total phenolic and flavonoid contents from extract was quantified and H(+) -K(+) ATPase inhibition assay was performed in presence...

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Detalles Bibliográficos
Autores principales: Yadav, Priyanka, Ganeshpurkar, Aditya, Rai, Gopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326759/
https://www.ncbi.nlm.nih.gov/pubmed/22518085
http://dx.doi.org/10.4103/0974-8490.94738
Descripción
Sumario:OBJECTIVE: This study was undertaken to study in vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. MATERIALS AND MATHODS: Total phenolic and flavonoid contents from extract was quantified and H(+) -K(+) ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract. RESULTS: Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard. CONCLUSIONS: These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump.

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