In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.

OBJECTIVE: This study was undertaken to study in vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. MATERIALS AND MATHODS: Total phenolic and flavonoid contents from extract was quantified and H(+) -K(+) ATPase inhibition assay was performed in presence...

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Autores principales: Yadav, Priyanka, Ganeshpurkar, Aditya, Rai, Gopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326759/
https://www.ncbi.nlm.nih.gov/pubmed/22518085
http://dx.doi.org/10.4103/0974-8490.94738
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author Yadav, Priyanka
Ganeshpurkar, Aditya
Rai, Gopal
author_facet Yadav, Priyanka
Ganeshpurkar, Aditya
Rai, Gopal
author_sort Yadav, Priyanka
collection PubMed
description OBJECTIVE: This study was undertaken to study in vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. MATERIALS AND MATHODS: Total phenolic and flavonoid contents from extract was quantified and H(+) -K(+) ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract. RESULTS: Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard. CONCLUSIONS: These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump.
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spelling pubmed-33267592012-04-19 In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Yadav, Priyanka Ganeshpurkar, Aditya Rai, Gopal Pharmacognosy Res Short Communication OBJECTIVE: This study was undertaken to study in vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. MATERIALS AND MATHODS: Total phenolic and flavonoid contents from extract was quantified and H(+) -K(+) ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract. RESULTS: Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard. CONCLUSIONS: These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3326759/ /pubmed/22518085 http://dx.doi.org/10.4103/0974-8490.94738 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Yadav, Priyanka
Ganeshpurkar, Aditya
Rai, Gopal
In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.
title In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.
title_full In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.
title_fullStr In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.
title_full_unstemmed In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.
title_short In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.
title_sort in vitro h(+) -k(+) atpase inhibitory potential of methanolic extract of cissus quadrangularis linn.
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326759/
https://www.ncbi.nlm.nih.gov/pubmed/22518085
http://dx.doi.org/10.4103/0974-8490.94738
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AT raigopal invitrohkatpaseinhibitorypotentialofmethanolicextractofcissusquadrangularislinn

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