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Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study
AIMS: To study and compare the effects of angiotensin II antagonist (Losartan) and angiotensin converting enzyme (ACE) inhibitor (Enalapril) on renal recovery following reversal of iatrogenic unilateral upper ureteric obstruction. MATERIALS AND METHODS: Unilateral upper ureteric obstruction was crea...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326821/ https://www.ncbi.nlm.nih.gov/pubmed/22529547 http://dx.doi.org/10.4103/0971-9261.93960 |
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author | Sinha, Anand Bajpai, Minu Panda, Shashank Ranjan, Saumya Sharma, Meher C. |
author_facet | Sinha, Anand Bajpai, Minu Panda, Shashank Ranjan, Saumya Sharma, Meher C. |
author_sort | Sinha, Anand |
collection | PubMed |
description | AIMS: To study and compare the effects of angiotensin II antagonist (Losartan) and angiotensin converting enzyme (ACE) inhibitor (Enalapril) on renal recovery following reversal of iatrogenic unilateral upper ureteric obstruction. MATERIALS AND METHODS: Unilateral upper ureteric obstruction was created in 96 adult Wistar rats that were reversed after predetermined intervals. Losartan and Enalapril were given to different subgroups of rats following relief of obstruction. Rats were sacrificed and kidneys were subjected to planimetric and histopathological analysis. RESULTS: Dorsal lumbotomy approach provided a rapid and safe approach to kidneys in rats. The planimetric and histopathological changes were most severe in the group of rats in whom obstruction was not relieved before sacrifice. Addition of Enalapril and Losartan significantly hastened the reversal of renal changes following relief of obstruction as compared with the group in which no treatment was given following reversal of blockade. CONCLUSIONS: Renin angiotensin system (RAS) is the major pathway responsible for renal damage following outflow obstruction. However, this damage can be reversed with the use of drugs acting on the RAS. |
format | Online Article Text |
id | pubmed-3326821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33268212012-04-23 Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study Sinha, Anand Bajpai, Minu Panda, Shashank Ranjan, Saumya Sharma, Meher C. J Indian Assoc Pediatr Surg Original Article AIMS: To study and compare the effects of angiotensin II antagonist (Losartan) and angiotensin converting enzyme (ACE) inhibitor (Enalapril) on renal recovery following reversal of iatrogenic unilateral upper ureteric obstruction. MATERIALS AND METHODS: Unilateral upper ureteric obstruction was created in 96 adult Wistar rats that were reversed after predetermined intervals. Losartan and Enalapril were given to different subgroups of rats following relief of obstruction. Rats were sacrificed and kidneys were subjected to planimetric and histopathological analysis. RESULTS: Dorsal lumbotomy approach provided a rapid and safe approach to kidneys in rats. The planimetric and histopathological changes were most severe in the group of rats in whom obstruction was not relieved before sacrifice. Addition of Enalapril and Losartan significantly hastened the reversal of renal changes following relief of obstruction as compared with the group in which no treatment was given following reversal of blockade. CONCLUSIONS: Renin angiotensin system (RAS) is the major pathway responsible for renal damage following outflow obstruction. However, this damage can be reversed with the use of drugs acting on the RAS. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3326821/ /pubmed/22529547 http://dx.doi.org/10.4103/0971-9261.93960 Text en Copyright: © Journal of Indian Association of Pediatric Surgeons http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sinha, Anand Bajpai, Minu Panda, Shashank Ranjan, Saumya Sharma, Meher C. Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study |
title | Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study |
title_full | Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study |
title_fullStr | Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study |
title_full_unstemmed | Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study |
title_short | Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study |
title_sort | unilateral ureteric obstruction: role of renin angiotensin system blockade on renal recovery: an experimental study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326821/ https://www.ncbi.nlm.nih.gov/pubmed/22529547 http://dx.doi.org/10.4103/0971-9261.93960 |
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