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Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study

AIMS: To study and compare the effects of angiotensin II antagonist (Losartan) and angiotensin converting enzyme (ACE) inhibitor (Enalapril) on renal recovery following reversal of iatrogenic unilateral upper ureteric obstruction. MATERIALS AND METHODS: Unilateral upper ureteric obstruction was crea...

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Autores principales: Sinha, Anand, Bajpai, Minu, Panda, Shashank, Ranjan, Saumya, Sharma, Meher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326821/
https://www.ncbi.nlm.nih.gov/pubmed/22529547
http://dx.doi.org/10.4103/0971-9261.93960
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author Sinha, Anand
Bajpai, Minu
Panda, Shashank
Ranjan, Saumya
Sharma, Meher C.
author_facet Sinha, Anand
Bajpai, Minu
Panda, Shashank
Ranjan, Saumya
Sharma, Meher C.
author_sort Sinha, Anand
collection PubMed
description AIMS: To study and compare the effects of angiotensin II antagonist (Losartan) and angiotensin converting enzyme (ACE) inhibitor (Enalapril) on renal recovery following reversal of iatrogenic unilateral upper ureteric obstruction. MATERIALS AND METHODS: Unilateral upper ureteric obstruction was created in 96 adult Wistar rats that were reversed after predetermined intervals. Losartan and Enalapril were given to different subgroups of rats following relief of obstruction. Rats were sacrificed and kidneys were subjected to planimetric and histopathological analysis. RESULTS: Dorsal lumbotomy approach provided a rapid and safe approach to kidneys in rats. The planimetric and histopathological changes were most severe in the group of rats in whom obstruction was not relieved before sacrifice. Addition of Enalapril and Losartan significantly hastened the reversal of renal changes following relief of obstruction as compared with the group in which no treatment was given following reversal of blockade. CONCLUSIONS: Renin angiotensin system (RAS) is the major pathway responsible for renal damage following outflow obstruction. However, this damage can be reversed with the use of drugs acting on the RAS.
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spelling pubmed-33268212012-04-23 Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study Sinha, Anand Bajpai, Minu Panda, Shashank Ranjan, Saumya Sharma, Meher C. J Indian Assoc Pediatr Surg Original Article AIMS: To study and compare the effects of angiotensin II antagonist (Losartan) and angiotensin converting enzyme (ACE) inhibitor (Enalapril) on renal recovery following reversal of iatrogenic unilateral upper ureteric obstruction. MATERIALS AND METHODS: Unilateral upper ureteric obstruction was created in 96 adult Wistar rats that were reversed after predetermined intervals. Losartan and Enalapril were given to different subgroups of rats following relief of obstruction. Rats were sacrificed and kidneys were subjected to planimetric and histopathological analysis. RESULTS: Dorsal lumbotomy approach provided a rapid and safe approach to kidneys in rats. The planimetric and histopathological changes were most severe in the group of rats in whom obstruction was not relieved before sacrifice. Addition of Enalapril and Losartan significantly hastened the reversal of renal changes following relief of obstruction as compared with the group in which no treatment was given following reversal of blockade. CONCLUSIONS: Renin angiotensin system (RAS) is the major pathway responsible for renal damage following outflow obstruction. However, this damage can be reversed with the use of drugs acting on the RAS. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3326821/ /pubmed/22529547 http://dx.doi.org/10.4103/0971-9261.93960 Text en Copyright: © Journal of Indian Association of Pediatric Surgeons http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sinha, Anand
Bajpai, Minu
Panda, Shashank
Ranjan, Saumya
Sharma, Meher C.
Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study
title Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study
title_full Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study
title_fullStr Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study
title_full_unstemmed Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study
title_short Unilateral ureteric obstruction: Role of renin angiotensin system blockade on renal recovery: An experimental study
title_sort unilateral ureteric obstruction: role of renin angiotensin system blockade on renal recovery: an experimental study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326821/
https://www.ncbi.nlm.nih.gov/pubmed/22529547
http://dx.doi.org/10.4103/0971-9261.93960
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