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Psychotropic activity of Argyreia speciosa roots in experimental animals

Argyreia speciosa (L.f.) Sweet (convolvulaceae) commonly known as Briddhadaraka is regarded as a “Rasayana” drug in the ayurvedic system of medicine to cure diseases of nervous system. In this study, hydroalcoholic root extract of A. speciosa was subjected to evaluate psychotropic effects in classic...

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Autores principales: Galani, Varsha J., Patel, Bharatkumar G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326887/
https://www.ncbi.nlm.nih.gov/pubmed/22529655
http://dx.doi.org/10.4103/0974-8520.93919
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author Galani, Varsha J.
Patel, Bharatkumar G.
author_facet Galani, Varsha J.
Patel, Bharatkumar G.
author_sort Galani, Varsha J.
collection PubMed
description Argyreia speciosa (L.f.) Sweet (convolvulaceae) commonly known as Briddhadaraka is regarded as a “Rasayana” drug in the ayurvedic system of medicine to cure diseases of nervous system. In this study, hydroalcoholic root extract of A. speciosa was subjected to evaluate psychotropic effects in classical experimental models. Effect of the extract on spontaneous motor activity, pentobarbital-induced sleeping time, motor coordination, exploratory behavior, and apomorphine-induced stereotypy were investigated in mice. Effect of the extract on catalepsy and haloperidol-induced catalepsy were studied in rats. Preliminary phytochemical and acute toxicity screenings were also performed. The extract (100, 200, and 500 mg/kg, p.o.) significantly decreased spontaneous motor activity, exploratory behavior, and prolonged pentobarbital sleeping time in mice. The extract also remarkably attenuated the intensity of apomorphine-induced stereotypy but had no effect on motor coordination. The extract produced catalepsy and potentiated haloperidol-induced catalepsy in rats. These results provide evidence that the hydroalcoholic extract of A. speciosa roots may contain psychoactive substances that are sedative in nature with possible neuroleptic properties.
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spelling pubmed-33268872012-04-23 Psychotropic activity of Argyreia speciosa roots in experimental animals Galani, Varsha J. Patel, Bharatkumar G. Ayu Pharmacological Research Argyreia speciosa (L.f.) Sweet (convolvulaceae) commonly known as Briddhadaraka is regarded as a “Rasayana” drug in the ayurvedic system of medicine to cure diseases of nervous system. In this study, hydroalcoholic root extract of A. speciosa was subjected to evaluate psychotropic effects in classical experimental models. Effect of the extract on spontaneous motor activity, pentobarbital-induced sleeping time, motor coordination, exploratory behavior, and apomorphine-induced stereotypy were investigated in mice. Effect of the extract on catalepsy and haloperidol-induced catalepsy were studied in rats. Preliminary phytochemical and acute toxicity screenings were also performed. The extract (100, 200, and 500 mg/kg, p.o.) significantly decreased spontaneous motor activity, exploratory behavior, and prolonged pentobarbital sleeping time in mice. The extract also remarkably attenuated the intensity of apomorphine-induced stereotypy but had no effect on motor coordination. The extract produced catalepsy and potentiated haloperidol-induced catalepsy in rats. These results provide evidence that the hydroalcoholic extract of A. speciosa roots may contain psychoactive substances that are sedative in nature with possible neuroleptic properties. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3326887/ /pubmed/22529655 http://dx.doi.org/10.4103/0974-8520.93919 Text en Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pharmacological Research
Galani, Varsha J.
Patel, Bharatkumar G.
Psychotropic activity of Argyreia speciosa roots in experimental animals
title Psychotropic activity of Argyreia speciosa roots in experimental animals
title_full Psychotropic activity of Argyreia speciosa roots in experimental animals
title_fullStr Psychotropic activity of Argyreia speciosa roots in experimental animals
title_full_unstemmed Psychotropic activity of Argyreia speciosa roots in experimental animals
title_short Psychotropic activity of Argyreia speciosa roots in experimental animals
title_sort psychotropic activity of argyreia speciosa roots in experimental animals
topic Pharmacological Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326887/
https://www.ncbi.nlm.nih.gov/pubmed/22529655
http://dx.doi.org/10.4103/0974-8520.93919
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