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A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis

OBJECTIVE: To compare the cure rates of oral single dose of metronidazole (2 g), tinidazole (2 g), secnidazole (2 g), and ornidazole (1.5 g) in cases of bacterial vaginosis. MATERIALS AND METHODS: This was a prospective, comparative, randomized clinical trial on 344 Indian women (86 women in each gr...

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Autores principales: Thulkar, Jyoti, Kriplani, Alka, Agarwal, Nutan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326921/
https://www.ncbi.nlm.nih.gov/pubmed/22529484
http://dx.doi.org/10.4103/0253-7613.93859
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author Thulkar, Jyoti
Kriplani, Alka
Agarwal, Nutan
author_facet Thulkar, Jyoti
Kriplani, Alka
Agarwal, Nutan
author_sort Thulkar, Jyoti
collection PubMed
description OBJECTIVE: To compare the cure rates of oral single dose of metronidazole (2 g), tinidazole (2 g), secnidazole (2 g), and ornidazole (1.5 g) in cases of bacterial vaginosis. MATERIALS AND METHODS: This was a prospective, comparative, randomized clinical trial on 344 Indian women (86 women in each group) who attended a gynecology outpatient department with complaint of abnormal vaginal discharge or who had abnormal vaginal discharge on Gynecological examination but they did not complaint of it. For diagnosis and cure rate of bacterial vaginosis, Amsel's criteria were used. Statistical analysis was done by Chi-square test of proportions. The cure rate was compared considering metronidazole cure rate as gold standard. RESULTS: At 1 week, the cure rate of tinidazole and ornidazole was 100% and at 4 weeks, it was 97.7% for both drugs (P<0.001). Secnidazole had cure rate of 80.2% at 4 weeks (P=NS). Metronidazole showed a cure rate of 77.9% at 4 weeks, which is the lowest of all four drugs. CONCLUSION: Tinidazole and ornidazole have better cure rate as compared to metronidazole in cases of bacterial vaginosis.
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spelling pubmed-33269212012-04-23 A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis Thulkar, Jyoti Kriplani, Alka Agarwal, Nutan Indian J Pharmacol Research Article OBJECTIVE: To compare the cure rates of oral single dose of metronidazole (2 g), tinidazole (2 g), secnidazole (2 g), and ornidazole (1.5 g) in cases of bacterial vaginosis. MATERIALS AND METHODS: This was a prospective, comparative, randomized clinical trial on 344 Indian women (86 women in each group) who attended a gynecology outpatient department with complaint of abnormal vaginal discharge or who had abnormal vaginal discharge on Gynecological examination but they did not complaint of it. For diagnosis and cure rate of bacterial vaginosis, Amsel's criteria were used. Statistical analysis was done by Chi-square test of proportions. The cure rate was compared considering metronidazole cure rate as gold standard. RESULTS: At 1 week, the cure rate of tinidazole and ornidazole was 100% and at 4 weeks, it was 97.7% for both drugs (P<0.001). Secnidazole had cure rate of 80.2% at 4 weeks (P=NS). Metronidazole showed a cure rate of 77.9% at 4 weeks, which is the lowest of all four drugs. CONCLUSION: Tinidazole and ornidazole have better cure rate as compared to metronidazole in cases of bacterial vaginosis. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3326921/ /pubmed/22529484 http://dx.doi.org/10.4103/0253-7613.93859 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Thulkar, Jyoti
Kriplani, Alka
Agarwal, Nutan
A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis
title A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis
title_full A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis
title_fullStr A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis
title_full_unstemmed A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis
title_short A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis
title_sort comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326921/
https://www.ncbi.nlm.nih.gov/pubmed/22529484
http://dx.doi.org/10.4103/0253-7613.93859
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