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Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study

BACKGROUND/AIMS: We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). METHODS: The immunoblot data for molecular expression (147 HCC/corresponding non-HCC tissues and 15 dy...

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Autores principales: Jang, Sun Kyung, Choi, Gi Hong, Choi, Junjeong, Quan, Xiaoyuan, Jang, Jeong Won, Kim, Bo Hyun, Jung, Guhung, Park, Young Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association for the Study of the Liver 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326987/
https://www.ncbi.nlm.nih.gov/pubmed/22511905
http://dx.doi.org/10.3350/kjhep.2012.18.1.63
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author Jang, Sun Kyung
Choi, Gi Hong
Choi, Junjeong
Quan, Xiaoyuan
Jang, Jeong Won
Kim, Bo Hyun
Jung, Guhung
Park, Young Min
author_facet Jang, Sun Kyung
Choi, Gi Hong
Choi, Junjeong
Quan, Xiaoyuan
Jang, Jeong Won
Kim, Bo Hyun
Jung, Guhung
Park, Young Min
author_sort Jang, Sun Kyung
collection PubMed
description BACKGROUND/AIMS: We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). METHODS: The immunoblot data for molecular expression (147 HCC/corresponding non-HCC tissues and 15 dysplastic nodules) and the sequencing data for p53 mutations (110 HCCs) were obtained from our previous study. Data analyses were restricted to cases with HCC differentiation grade III (n=47), due to its high p53 mutation rate. RESULTS: Nineteen of the 47 patients (40.4%) -comprising 12 in the liver and 7 in distant organs-had relapsed at 1-2 years after surgery. There was no relationship between p53 mutation and postoperative recurrence in the grade III HCCs. Seven (87.5%) of the eight relapsed cases with Notch1, Snail, and p53 (wild) co-expression experienced recurrence only within the liver, and all tumors were smaller than 5 cm in diameter. Extrahepatic relapse occurred mostly in HCC patients with tumors larger than 5 cm in diameter, without any deviation in the NSP pattern. CONCLUSIONS: The results of this preliminary study suggest that the co-expression of Notch1, Snail, and p53 (wild) is not inferior to the patterns with p53 mutation as an indicator of postoperative recurrence of grade III HCC.
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spelling pubmed-33269872012-04-17 Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study Jang, Sun Kyung Choi, Gi Hong Choi, Junjeong Quan, Xiaoyuan Jang, Jeong Won Kim, Bo Hyun Jung, Guhung Park, Young Min Korean J Hepatol Original Article BACKGROUND/AIMS: We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). METHODS: The immunoblot data for molecular expression (147 HCC/corresponding non-HCC tissues and 15 dysplastic nodules) and the sequencing data for p53 mutations (110 HCCs) were obtained from our previous study. Data analyses were restricted to cases with HCC differentiation grade III (n=47), due to its high p53 mutation rate. RESULTS: Nineteen of the 47 patients (40.4%) -comprising 12 in the liver and 7 in distant organs-had relapsed at 1-2 years after surgery. There was no relationship between p53 mutation and postoperative recurrence in the grade III HCCs. Seven (87.5%) of the eight relapsed cases with Notch1, Snail, and p53 (wild) co-expression experienced recurrence only within the liver, and all tumors were smaller than 5 cm in diameter. Extrahepatic relapse occurred mostly in HCC patients with tumors larger than 5 cm in diameter, without any deviation in the NSP pattern. CONCLUSIONS: The results of this preliminary study suggest that the co-expression of Notch1, Snail, and p53 (wild) is not inferior to the patterns with p53 mutation as an indicator of postoperative recurrence of grade III HCC. The Korean Association for the Study of the Liver 2012-03 2012-03-22 /pmc/articles/PMC3326987/ /pubmed/22511905 http://dx.doi.org/10.3350/kjhep.2012.18.1.63 Text en Copyright © 2012 by The Korean Association for the Study of the Liver http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jang, Sun Kyung
Choi, Gi Hong
Choi, Junjeong
Quan, Xiaoyuan
Jang, Jeong Won
Kim, Bo Hyun
Jung, Guhung
Park, Young Min
Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
title Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
title_full Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
title_fullStr Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
title_full_unstemmed Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
title_short Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
title_sort co-expression patterns of notch1, snail, and p53 in grade iii hepatocellular carcinoma with postoperative recurrence: a preliminary study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326987/
https://www.ncbi.nlm.nih.gov/pubmed/22511905
http://dx.doi.org/10.3350/kjhep.2012.18.1.63
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