Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells

The molecular mechanisms that drive triple-negative, basal-like breast cancer progression are elusive. Few molecular targets have been identified for the prevention or treatment of this disease. Here we developed a series of isogenic basal-like human mammary epithelial cells (HMECs) with altered tra...

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Detalles Bibliográficos
Autores principales: Lin, Shu, Yang, Junhua, Elkahloun, Abdel G., Bandyopadhyay, Abhik, Wang, Long, Cornell, John E., Yeh, I-Tien, Agyin, Joseph, Tomlinson, Gail, Sun, Lu-Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327327/
https://www.ncbi.nlm.nih.gov/pubmed/22357622
http://dx.doi.org/10.1091/mbc.E11-10-0849

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