A Systems Biology Approach to Characterize the Regulatory Networks Leading to Trabectedin Resistance in an In Vitro Model of Myxoid Liposarcoma

Trabectedin, a new antitumor compound originally derived from a marine tunicate, is clinically effective in soft tissue sarcoma. The drug has shown a high selectivity for myxoid liposarcoma, characterized by the translocation t(12;16)(q13; p11) leading to the expression of FUS-CHOP fusion gene. Trab...

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Detalles Bibliográficos
Autores principales: Uboldi, Sarah, Calura, Enrica, Beltrame, Luca, Fuso Nerini, Ilaria, Marchini, Sergio, Cavalieri, Duccio, Erba, Eugenio, Chiorino, Giovanna, Ostano, Paola, D'Angelo, Daniela, D'Incalci, Maurizio, Romualdi, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327679/
https://www.ncbi.nlm.nih.gov/pubmed/22523595
http://dx.doi.org/10.1371/journal.pone.0035423

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