Identification of JAK2 as a Mediator of FIP1L1-PDGFRA-Induced Eosinophil Growth and Function in CEL

The Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha fusion gene (F/P) arising in the pluripotent hematopoietic stem cell (HSC),causes 14% to 60% of patients with hypereosinophilia syndrome (HES). These patients, classified as having F/P (+) chronic eosinophilic leukemia (CEL), pres...

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Detalles Bibliográficos
Autores principales: Li, Bin, Zhang, Guangsen, Li, Cui, He, Dan, Li, Xinying, Zhang, Chunfang, Tang, Faqing, Deng, Xiyun, Lu, Jingchen, Tang, Youhong, Li, Ruijuan, Chen, Zhuchu, Duan, Chaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327703/
https://www.ncbi.nlm.nih.gov/pubmed/22523564
http://dx.doi.org/10.1371/journal.pone.0034912

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