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The Interaction Properties of the Human Rab GTPase Family – A Comparative Analysis Reveals Determinants of Molecular Binding Selectivity

BACKGROUND: Rab GTPases constitute the largest subfamily of the Ras protein superfamily. Rab proteins regulate organelle biogenesis and transport, and display distinct binding preferences for effector and activator proteins, many of which have not been elucidated yet. The underlying molecular recogn...

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Detalles Bibliográficos
Autores principales: Stein, Matthias, Pilli, Manohar, Bernauer, Sabine, Habermann, Bianca H., Zerial, Marino, Wade, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327705/
https://www.ncbi.nlm.nih.gov/pubmed/22523562
http://dx.doi.org/10.1371/journal.pone.0034870