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Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function
BACKGROUND: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficienc...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327709/ https://www.ncbi.nlm.nih.gov/pubmed/22523561 http://dx.doi.org/10.1371/journal.pone.0034851 |
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author | Warrander, Lynne K. Batra, Gauri Bernatavicius, Giovanna Greenwood, Susan L. Dutton, Philip Jones, Rebecca L. Sibley, Colin P. Heazell, Alexander E. P. |
author_facet | Warrander, Lynne K. Batra, Gauri Bernatavicius, Giovanna Greenwood, Susan L. Dutton, Philip Jones, Rebecca L. Sibley, Colin P. Heazell, Alexander E. P. |
author_sort | Warrander, Lynne K. |
collection | PubMed |
description | BACKGROUND: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. To date there have been no studies of placental structure in cases of DFM. OBJECTIVE: To determine whether maternal perception of reduced fetal movements (RFM) is associated with abnormalities in placental structure and function. DESIGN: Placentas were collected from women with RFM after 28 weeks gestation if delivery occurred within 1 week. Women with normal movements served as a control group. Placentas were weighed and photographs taken. Microscopic structure was evaluated by immunohistochemical staining and image analysis. System A amino acid transporter activity was measured as a marker of placental function. Placentas from all pregnancies with RFM (irrespective of outcome) had greater area with signs of infarction (3.5% vs. 0.6%; p<0.01), a higher density of syncytial knots (p<0.001) and greater proliferation index (p<0.01). Villous vascularity (p<0.001), trophoblast area (p<0.01) and system A activity (p<0.01) were decreased in placentas from RFM compared to controls irrespective of outcome of pregnancy. CONCLUSIONS: This study provides evidence of abnormal placental morphology and function in women with RFM and supports the proposition of a causal association between placental insufficiency and RFM. This suggests that women presenting with RFM require further investigation to identify those with placental insufficiency. |
format | Online Article Text |
id | pubmed-3327709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33277092012-04-20 Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function Warrander, Lynne K. Batra, Gauri Bernatavicius, Giovanna Greenwood, Susan L. Dutton, Philip Jones, Rebecca L. Sibley, Colin P. Heazell, Alexander E. P. PLoS One Research Article BACKGROUND: Maternal perception of reduced fetal movement (RFM) is associated with increased risk of stillbirth and fetal growth restriction (FGR). DFM is thought to represent fetal compensation to conserve energy due to insufficient oxygen and nutrient transfer resulting from placental insufficiency. To date there have been no studies of placental structure in cases of DFM. OBJECTIVE: To determine whether maternal perception of reduced fetal movements (RFM) is associated with abnormalities in placental structure and function. DESIGN: Placentas were collected from women with RFM after 28 weeks gestation if delivery occurred within 1 week. Women with normal movements served as a control group. Placentas were weighed and photographs taken. Microscopic structure was evaluated by immunohistochemical staining and image analysis. System A amino acid transporter activity was measured as a marker of placental function. Placentas from all pregnancies with RFM (irrespective of outcome) had greater area with signs of infarction (3.5% vs. 0.6%; p<0.01), a higher density of syncytial knots (p<0.001) and greater proliferation index (p<0.01). Villous vascularity (p<0.001), trophoblast area (p<0.01) and system A activity (p<0.01) were decreased in placentas from RFM compared to controls irrespective of outcome of pregnancy. CONCLUSIONS: This study provides evidence of abnormal placental morphology and function in women with RFM and supports the proposition of a causal association between placental insufficiency and RFM. This suggests that women presenting with RFM require further investigation to identify those with placental insufficiency. Public Library of Science 2012-04-16 /pmc/articles/PMC3327709/ /pubmed/22523561 http://dx.doi.org/10.1371/journal.pone.0034851 Text en Warrander et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Warrander, Lynne K. Batra, Gauri Bernatavicius, Giovanna Greenwood, Susan L. Dutton, Philip Jones, Rebecca L. Sibley, Colin P. Heazell, Alexander E. P. Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function |
title | Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function |
title_full | Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function |
title_fullStr | Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function |
title_full_unstemmed | Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function |
title_short | Maternal Perception of Reduced Fetal Movements Is Associated with Altered Placental Structure and Function |
title_sort | maternal perception of reduced fetal movements is associated with altered placental structure and function |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327709/ https://www.ncbi.nlm.nih.gov/pubmed/22523561 http://dx.doi.org/10.1371/journal.pone.0034851 |
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