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Impact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells

BACKGROUND: Colorectal cancers are often chemoresistant toward antitumour drugs that are substrates for ABCB1-mediated multidrug resistance (MDR). Activation of the Wnt/β-catenin pathway is frequently observed in colorectal cancers. This study investigates the impact of activated, gain-of-function β...

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Detalles Bibliográficos
Autores principales:	Stein, U, Fleuter, C, Siegel, F, Smith, J, Kopacek, A, Scudiero, D A, Hite, K M, Schlag, P M, Shoemaker, R H, Walther, W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327894/ https://www.ncbi.nlm.nih.gov/pubmed/22460269 http://dx.doi.org/10.1038/bjc.2012.81

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