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Oral tolerance to food protein
Oral tolerance is the state of local and systemic immune unresponsiveness that is induced by oral administration of innocuous antigen such as food proteins. An analogous but more local process also regulates responses to commensal bacteria in the large intestine and, together, mucosally induced tole...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328017/ https://www.ncbi.nlm.nih.gov/pubmed/22318493 http://dx.doi.org/10.1038/mi.2012.4 |
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author | Pabst, O Mowat, A M |
author_facet | Pabst, O Mowat, A M |
author_sort | Pabst, O |
collection | PubMed |
description | Oral tolerance is the state of local and systemic immune unresponsiveness that is induced by oral administration of innocuous antigen such as food proteins. An analogous but more local process also regulates responses to commensal bacteria in the large intestine and, together, mucosally induced tolerance appears to prevent intestinal disorders such as food allergy, celiac disease, and inflammatory bowel diseases. Here we discuss the anatomical basis of antigen uptake and recognition in oral tolerance and highlight possible mechanisms underlying the immunosuppression. We propose a model of stepwise induction of oral tolerance in which specialized populations of mucosal dendritic cells and the unique microenvironment of draining mesenteric lymph nodes combine to generate regulatory T cells that undergo subsequent expansion in the small intestinal lamina propria. The local and systemic effects of these regulatory T cells prevent potentially dangerous hypersensitivity reactions to harmless antigens derived from the intestine and hence are crucial players in immune homeostasis. |
format | Online Article Text |
id | pubmed-3328017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-33280172012-04-17 Oral tolerance to food protein Pabst, O Mowat, A M Mucosal Immunol Review Oral tolerance is the state of local and systemic immune unresponsiveness that is induced by oral administration of innocuous antigen such as food proteins. An analogous but more local process also regulates responses to commensal bacteria in the large intestine and, together, mucosally induced tolerance appears to prevent intestinal disorders such as food allergy, celiac disease, and inflammatory bowel diseases. Here we discuss the anatomical basis of antigen uptake and recognition in oral tolerance and highlight possible mechanisms underlying the immunosuppression. We propose a model of stepwise induction of oral tolerance in which specialized populations of mucosal dendritic cells and the unique microenvironment of draining mesenteric lymph nodes combine to generate regulatory T cells that undergo subsequent expansion in the small intestinal lamina propria. The local and systemic effects of these regulatory T cells prevent potentially dangerous hypersensitivity reactions to harmless antigens derived from the intestine and hence are crucial players in immune homeostasis. Nature Publishing Group 2012-05 2012-02-08 /pmc/articles/PMC3328017/ /pubmed/22318493 http://dx.doi.org/10.1038/mi.2012.4 Text en Copyright © 2012 Society for Mucosal Immunology http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Review Pabst, O Mowat, A M Oral tolerance to food protein |
title | Oral tolerance to food protein |
title_full | Oral tolerance to food protein |
title_fullStr | Oral tolerance to food protein |
title_full_unstemmed | Oral tolerance to food protein |
title_short | Oral tolerance to food protein |
title_sort | oral tolerance to food protein |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328017/ https://www.ncbi.nlm.nih.gov/pubmed/22318493 http://dx.doi.org/10.1038/mi.2012.4 |
work_keys_str_mv | AT pabsto oraltolerancetofoodprotein AT mowatam oraltolerancetofoodprotein |