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Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming

Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation...

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Detalles Bibliográficos
Autores principales: Kretsovali, Androniki, Hadjimichael, Christiana, Charmpilas, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328162/
https://www.ncbi.nlm.nih.gov/pubmed/22550500
http://dx.doi.org/10.1155/2012/184154
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author Kretsovali, Androniki
Hadjimichael, Christiana
Charmpilas, Nikolaos
author_facet Kretsovali, Androniki
Hadjimichael, Christiana
Charmpilas, Nikolaos
author_sort Kretsovali, Androniki
collection PubMed
description Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and tissue-specific stem cells along the neuronal, cardiomyocytic, and hepatic lineages. They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors. In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4. Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. Deciphering the mechanisms of HDAC inhibitor actions is very important to enable their exploitation for efficient and simple tissue regeneration therapies.
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spelling pubmed-33281622012-05-01 Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming Kretsovali, Androniki Hadjimichael, Christiana Charmpilas, Nikolaos Stem Cells Int Review Article Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and tissue-specific stem cells along the neuronal, cardiomyocytic, and hepatic lineages. They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors. In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4. Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. Deciphering the mechanisms of HDAC inhibitor actions is very important to enable their exploitation for efficient and simple tissue regeneration therapies. Hindawi Publishing Corporation 2012 2012-03-08 /pmc/articles/PMC3328162/ /pubmed/22550500 http://dx.doi.org/10.1155/2012/184154 Text en Copyright © 2012 Androniki Kretsovali et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kretsovali, Androniki
Hadjimichael, Christiana
Charmpilas, Nikolaos
Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
title Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
title_full Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
title_fullStr Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
title_full_unstemmed Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
title_short Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
title_sort histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328162/
https://www.ncbi.nlm.nih.gov/pubmed/22550500
http://dx.doi.org/10.1155/2012/184154
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