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Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming
Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328162/ https://www.ncbi.nlm.nih.gov/pubmed/22550500 http://dx.doi.org/10.1155/2012/184154 |
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author | Kretsovali, Androniki Hadjimichael, Christiana Charmpilas, Nikolaos |
author_facet | Kretsovali, Androniki Hadjimichael, Christiana Charmpilas, Nikolaos |
author_sort | Kretsovali, Androniki |
collection | PubMed |
description | Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and tissue-specific stem cells along the neuronal, cardiomyocytic, and hepatic lineages. They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors. In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4. Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. Deciphering the mechanisms of HDAC inhibitor actions is very important to enable their exploitation for efficient and simple tissue regeneration therapies. |
format | Online Article Text |
id | pubmed-3328162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33281622012-05-01 Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming Kretsovali, Androniki Hadjimichael, Christiana Charmpilas, Nikolaos Stem Cells Int Review Article Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and tissue-specific stem cells along the neuronal, cardiomyocytic, and hepatic lineages. They have been used to facilitate embryo development following somatic cell nuclear transfer and induced pluripotent stem cell derivation by ectopic expression of pluripotency factors. In the latter method, these molecules not only increase effectiveness, but can also render the induction independent of the oncogenes c-Myc and Klf4. Here we review the molecular pathways that are involved in the functions of HDAC inhibitors on stem cell differentiation and reprogramming of somatic cells into pluripotency. Deciphering the mechanisms of HDAC inhibitor actions is very important to enable their exploitation for efficient and simple tissue regeneration therapies. Hindawi Publishing Corporation 2012 2012-03-08 /pmc/articles/PMC3328162/ /pubmed/22550500 http://dx.doi.org/10.1155/2012/184154 Text en Copyright © 2012 Androniki Kretsovali et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kretsovali, Androniki Hadjimichael, Christiana Charmpilas, Nikolaos Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
title | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
title_full | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
title_fullStr | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
title_full_unstemmed | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
title_short | Histone Deacetylase Inhibitors in Cell Pluripotency, Differentiation, and Reprogramming |
title_sort | histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328162/ https://www.ncbi.nlm.nih.gov/pubmed/22550500 http://dx.doi.org/10.1155/2012/184154 |
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