Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling

Several aldo–keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low K(m) and k(cat) values. Only AKR1B10 and 1B12, with all-trans-retinaldehyde, and AKR1C3, with 9-cis-retinaldehyde, display high catalytic efficiency. Major structural determinants f...

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Detalles Bibliográficos
Autores principales: Ruiz, F. Xavier, Porté, Sergio, Parés, Xavier, Farrés, Jaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328219/
https://www.ncbi.nlm.nih.gov/pubmed/22529810
http://dx.doi.org/10.3389/fphar.2012.00058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328219/
https://www.ncbi.nlm.nih.gov/pubmed/22529810
http://dx.doi.org/10.3389/fphar.2012.00058

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