Cargando…

Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling

Several aldo–keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low K(m) and k(cat) values. Only AKR1B10 and 1B12, with all-trans-retinaldehyde, and AKR1C3, with 9-cis-retinaldehyde, display high catalytic efficiency. Major structural determinants f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruiz, F. Xavier, Porté, Sergio, Parés, Xavier, Farrés, Jaume
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328219/ https://www.ncbi.nlm.nih.gov/pubmed/22529810 http://dx.doi.org/10.3389/fphar.2012.00058

Ejemplares similares

Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition
por: Ruiz, Francesc Xavier, et al.
Publicado: (2021)

Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase
por: Giménez-Dejoz, Joan, et al.
Publicado: (2015)

Regulation of Aldo–Keto Reductases in Human Diseases
por: Chen, Wei-Dong, et al.
Publicado: (2012)

Aldo-Keto Reductases 1B in Endocrinology and Metabolism
por: Pastel, Emilie, et al.
Publicado: (2012)

Role of Aldo–Keto Reductase Enzymes in Mediating the Timing of Parturition
por: Byrns, Michael C.
Publicado: (2012)

Editorial on research topic: aldo-keto reductases and role in human disease
por: Jin, Yi
Publicado: (2013)

Aldo-Keto Reductases in the Eye
por: Huang, Shun Ping, et al.
Publicado: (2010)

Aldo–Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers
por: Matsunaga, Toshiyuki, et al.
Publicado: (2012)

An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C in Vitis vinifera
por: Jia, Yong, et al.
Publicado: (2019)

Aldo-keto reductase (AKR) superfamily: Genomics and annotation
por: Mindnich, Rebekka D, et al.
Publicado: (2009)

Acceleration of an aldo-keto reductase by minimal loop engineering
por: Krump, C., et al.
Publicado: (2014)

Structural studies of codeinone reductase reveal novel insights into aldo-keto reductase function in benzylisoquinoline alkaloid biosynthesis
por: Carr, Samuel C., et al.
Publicado: (2021)

Aldo-Keto Reductases 1B in Adrenal Cortex Physiology
por: Pastel, Emilie, et al.
Publicado: (2016)

The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones
por: Zhang, Li, et al.
Publicado: (2012)

Semi-rational engineering an aldo–keto reductase for stereocomplementary reduction of α-keto amide compounds
por: Bai, Ruixuan, et al.
Publicado: (2023)

Aldo–Keto Reductase AKR1C1–AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy
por: Zeng, Chen-Ming, et al.
Publicado: (2017)

Human Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons
por: Penning, Trevor M.
Publicado: (2014)

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism
por: Roberts, Adam J., et al.
Publicado: (2018)

New Insights into the Role of the Trypanosoma cruzi Aldo-Keto Reductase TcAKR
por: Díaz-Viraqué, Florencia, et al.
Publicado: (2023)

The Coptotermes gestroi aldo–keto reductase: a multipurpose enzyme for biorefinery applications
por: Tramontina, Robson, et al.
Publicado: (2017)

Aldo‐keto reductase enzymes detoxify glyphosate and improve herbicide resistance in plants
por: Vemanna, Ramu S., et al.
Publicado: (2017)

Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish
por: Li, Xiaogang, et al.
Publicado: (2020)

Structure–function characterization of an aldo–keto reductase involved in detoxification of the mycotoxin, deoxynivalenol
por: Abraham, Nadine, et al.
Publicado: (2022)

The Role of Cytochromes P450 and Aldo-Keto Reductases in Prognosis of Breast Carcinoma Patients
por: Hlaváč, Viktor, et al.
Publicado: (2014)

Identification of the Aldo-Keto Reductase Responsible for d-Galacturonic Acid Conversion to l-Galactonate in Saccharomyces cerevisiae
por: Rippert, Dorthe, et al.
Publicado: (2021)

Aldehyde Dehydrogenase and Aldo-Keto Reductase Enzymes: Basic Concepts and Emerging Roles in Diabetic Retinopathy
por: Karan, Burak Mugdat, et al.
Publicado: (2023)

Quantitative Evaluation of Aldo–keto Reductase Expression in Hepatocellular Carcinoma (HCC) Cell Lines
por: Yang, Lei, et al.
Publicado: (2013)

Effects of ligand binding on the stability of aldo–keto reductases: Implications for stabilizer or destabilizer chaperones
por: Kabir, Aurangazeb, et al.
Publicado: (2016)

Aldo‐keto reductases‐mediated cytotoxicity of 2‐deoxyglucose: A novel anticancer mechanism
por: Zhang, Shi‐Qing, et al.
Publicado: (2018)

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis
por: Gagliardi, Mara, et al.
Publicado: (2019)

Michaelis-Menten Kinetics Measurements of Aldo-Keto Reductases for Various Substrates in Murine Tissue
por: Morgenstern, Jakob, et al.
Publicado: (2020)

Aldo-Keto Reductase 1C15 Characterization and Protection in Ischemic Brain Injury
por: Yang, Tuo, et al.
Publicado: (2023)

Analysis of Aldo–Keto Reductase Gene Family and Their Responses to Salt, Drought, and Abscisic Acid Stresses in Medicago truncatula
por: Yu, Jie, et al.
Publicado: (2020)

Babesia microti Aldo-keto Reductase-Like Protein Involved in Antioxidant and Anti-parasite Response
por: Huang, Qiang, et al.
Publicado: (2017)

An aldo-keto reductase is responsible for Fusarium toxin-degrading activity in a soil Sphingomonas strain
por: He, Wei-Jie, et al.
Publicado: (2017)

Regulation Network and Prognostic Significance of Aldo-Keto Reductase (AKR) Superfamily Genes in Hepatocellular Carcinoma
por: Dai, Tianxing, et al.
Publicado: (2021)

Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases
por: Detlefsen, Andrea J., et al.
Publicado: (2023)

The Specific Binding and Promotion Effect of Azoles on Human Aldo-Keto Reductase 7A2
por: Wu, Wanying, et al.
Publicado: (2023)

Impact of cytotoxic chemotherapy on aldo-keto reductase family 1 member B10 expression
por: Robinson, Kathy, et al.
Publicado: (2023)

Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization
por: Heibein, Allan D, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9adoejre8tthd2a4hfvrrd787v