Cargando…
EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence
BACKGROUND: Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and tendency towards recurrence. AIMS: Studying the role played by EGFR, CD10 and Ki67 in the recurrence of ameloblastoma. METHODS: This study was carried out on 22 retrospective cases of mandibular ameloblastom...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328247/ https://www.ncbi.nlm.nih.gov/pubmed/22300665 http://dx.doi.org/10.1186/1746-1596-7-14 |
_version_ | 1782229711921872896 |
---|---|
author | Abdel-Aziz, Azza Amin, Maha M |
author_facet | Abdel-Aziz, Azza Amin, Maha M |
author_sort | Abdel-Aziz, Azza |
collection | PubMed |
description | BACKGROUND: Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and tendency towards recurrence. AIMS: Studying the role played by EGFR, CD10 and Ki67 in the recurrence of ameloblastoma. METHODS: This study was carried out on 22 retrospective cases of mandibular ameloblastoma from the period from Jan 2002 to Jan 2008 with follow up period until Jan 2011 (3 to 8 years follow up peroid). Archival materials were obtained from pathology department, Mansoura university. Paraffin sections of tumor tissue from all cases were submitted for routine H&E stains and immunohistochemistry using EGFR, CD10 and Ki67 monoclonal antibodies. Statistical analysis using of clinical data for all patients, tumor type, EGFR, CD10 and Ki67 expression in relation to recurrence were evaluated. RESULTS: Among the 22 cases, 10 cases were males and 12 were females with sex ratio 1:1.2. Age ranged from 34 to 59 years old with a mean age 44.18 year. Five cases showed local recurrence within studied period and proved by biopsy. No statistically significant relation was found between local recurrence and patient age, tumor size, tumor type, EGFR expression. There was a significant relation between CD10 expression as well as Ki67 labelling index and recurrence (P value = 0.003, 0.000 respectively). CONCLUSION: Evaluation of CD10 and Ki67 status together with conventional histological evaluation can help in providing more information about the biologic behavior of the tumor, while EGFR could be a target of an expanding class of anticancer therapies. Since ameloblastomas are EGFR-positive tumors, anti-EGFR agents could be considered to reduce the size of large tumors and to treat unresectable tumors that are in close proximity to vital structures. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1902106905645651 |
format | Online Article Text |
id | pubmed-3328247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33282472012-04-18 EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence Abdel-Aziz, Azza Amin, Maha M Diagn Pathol Research BACKGROUND: Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and tendency towards recurrence. AIMS: Studying the role played by EGFR, CD10 and Ki67 in the recurrence of ameloblastoma. METHODS: This study was carried out on 22 retrospective cases of mandibular ameloblastoma from the period from Jan 2002 to Jan 2008 with follow up period until Jan 2011 (3 to 8 years follow up peroid). Archival materials were obtained from pathology department, Mansoura university. Paraffin sections of tumor tissue from all cases were submitted for routine H&E stains and immunohistochemistry using EGFR, CD10 and Ki67 monoclonal antibodies. Statistical analysis using of clinical data for all patients, tumor type, EGFR, CD10 and Ki67 expression in relation to recurrence were evaluated. RESULTS: Among the 22 cases, 10 cases were males and 12 were females with sex ratio 1:1.2. Age ranged from 34 to 59 years old with a mean age 44.18 year. Five cases showed local recurrence within studied period and proved by biopsy. No statistically significant relation was found between local recurrence and patient age, tumor size, tumor type, EGFR expression. There was a significant relation between CD10 expression as well as Ki67 labelling index and recurrence (P value = 0.003, 0.000 respectively). CONCLUSION: Evaluation of CD10 and Ki67 status together with conventional histological evaluation can help in providing more information about the biologic behavior of the tumor, while EGFR could be a target of an expanding class of anticancer therapies. Since ameloblastomas are EGFR-positive tumors, anti-EGFR agents could be considered to reduce the size of large tumors and to treat unresectable tumors that are in close proximity to vital structures. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1902106905645651 BioMed Central 2012-02-02 /pmc/articles/PMC3328247/ /pubmed/22300665 http://dx.doi.org/10.1186/1746-1596-7-14 Text en Copyright ©2012 Abdel-Aziz and Amin; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Abdel-Aziz, Azza Amin, Maha M EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence |
title | EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence |
title_full | EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence |
title_fullStr | EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence |
title_full_unstemmed | EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence |
title_short | EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence |
title_sort | egfr, cd10 and proliferation marker ki67 expression in ameloblastoma: possible role in local recurrence |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328247/ https://www.ncbi.nlm.nih.gov/pubmed/22300665 http://dx.doi.org/10.1186/1746-1596-7-14 |
work_keys_str_mv | AT abdelazizazza egfrcd10andproliferationmarkerki67expressioninameloblastomapossibleroleinlocalrecurrence AT aminmaham egfrcd10andproliferationmarkerki67expressioninameloblastomapossibleroleinlocalrecurrence |