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HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

BACKGROUND: Nef is an HIV-1 accessory protein essential for viral replication and AIDS progression. Nef interacts with a multitude of host cell signaling partners, including members of the Src kinase family. Nef preferentially activates Hck, a Src-family kinase (SFK) strongly expressed in macrophage...

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Detalles Bibliográficos
Autores principales:	Pene-Dumitrescu, Teodora, Shu, Sherry T, Wales, Thomas E, Alvarado, John J, Shi, Haibin, Narute, Purushottam, Moroco, Jamie A, Yeh, Joanne I, Engen, John R, Smithgall, Thomas E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328272/ https://www.ncbi.nlm.nih.gov/pubmed/22420777 http://dx.doi.org/10.1186/1472-6769-12-1

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