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Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis
Recent morphologic and molecular genetic studies have led to a paradigm shift in our conceptualization of the carcinogenesis and histogenesis of pelvic (non-uterine) serous carcinomas. It appears that both low-grade and high-grade pelvic serous carcinomas that have traditionally been classified as o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328281/ https://www.ncbi.nlm.nih.gov/pubmed/22405464 http://dx.doi.org/10.1186/1756-8722-5-8 |
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author | Li, Jie Fadare, Oluwole Xiang, Li Kong, Beihua Zheng, Wenxin |
author_facet | Li, Jie Fadare, Oluwole Xiang, Li Kong, Beihua Zheng, Wenxin |
author_sort | Li, Jie |
collection | PubMed |
description | Recent morphologic and molecular genetic studies have led to a paradigm shift in our conceptualization of the carcinogenesis and histogenesis of pelvic (non-uterine) serous carcinomas. It appears that both low-grade and high-grade pelvic serous carcinomas that have traditionally been classified as ovarian in origin, actually originate, at least in a significant subset, from the distal fallopian tube. Clonal expansions of the tubal secretory cell probably give rise to serous carcinomas, and the degree of ciliated conversion is a function of the degree to which the genetic hits deregulate normal differentiation. In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications. |
format | Online Article Text |
id | pubmed-3328281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33282812012-04-18 Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis Li, Jie Fadare, Oluwole Xiang, Li Kong, Beihua Zheng, Wenxin J Hematol Oncol Review Recent morphologic and molecular genetic studies have led to a paradigm shift in our conceptualization of the carcinogenesis and histogenesis of pelvic (non-uterine) serous carcinomas. It appears that both low-grade and high-grade pelvic serous carcinomas that have traditionally been classified as ovarian in origin, actually originate, at least in a significant subset, from the distal fallopian tube. Clonal expansions of the tubal secretory cell probably give rise to serous carcinomas, and the degree of ciliated conversion is a function of the degree to which the genetic hits deregulate normal differentiation. In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications. BioMed Central 2012-03-09 /pmc/articles/PMC3328281/ /pubmed/22405464 http://dx.doi.org/10.1186/1756-8722-5-8 Text en Copyright ©2012 Li et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Li, Jie Fadare, Oluwole Xiang, Li Kong, Beihua Zheng, Wenxin Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis |
title | Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis |
title_full | Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis |
title_fullStr | Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis |
title_full_unstemmed | Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis |
title_short | Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis |
title_sort | ovarian serous carcinoma: recent concepts on its origin and carcinogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328281/ https://www.ncbi.nlm.nih.gov/pubmed/22405464 http://dx.doi.org/10.1186/1756-8722-5-8 |
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