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Infant feeding bottle design, growth and behaviour: results from a randomised trial

BACKGROUND: Whether the design of an anti-vacuum infant feeding bottle influences infant milk intake, growth or behavior is unknown, and was the subject of this randomized trial. METHODS: SUBJECTS: 63 (36 male) healthy, exclusively formula-fed term infants. INTERVENTION: Randomisation to use Bottle...

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Autores principales: Fewtrell, MS, Kennedy, K, Nicholl, R, Khakoo, A, Lucas, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328286/
https://www.ncbi.nlm.nih.gov/pubmed/22424116
http://dx.doi.org/10.1186/1756-0500-5-150
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author Fewtrell, MS
Kennedy, K
Nicholl, R
Khakoo, A
Lucas, A
author_facet Fewtrell, MS
Kennedy, K
Nicholl, R
Khakoo, A
Lucas, A
author_sort Fewtrell, MS
collection PubMed
description BACKGROUND: Whether the design of an anti-vacuum infant feeding bottle influences infant milk intake, growth or behavior is unknown, and was the subject of this randomized trial. METHODS: SUBJECTS: 63 (36 male) healthy, exclusively formula-fed term infants. INTERVENTION: Randomisation to use Bottle A (n = 31), one-way air valve: Philips Avent) versus Bottle B (n = 32), internal venting system: Dr Browns). 74 breast-fed reference infants were recruited, with randomisation (n = 24) to bottle A (n = 11) or B (n = 13) if bottle-feeding was subsequently introduced. RANDOMISATION: stratified by gender and parity; computer-based telephone randomisation by independent clinical trials unit. SETTING: Infant home. PRIMARY OUTCOME MEASURE: infant weight gain to 4 weeks. SECONDARY OUTCOMES: (i) milk intake (ii) infant behaviour measured at 2 weeks (validated 3-day diary); (iii) risk of infection; (iv) continuation of breastfeeding following introduction of mixed feeding. RESULTS: NUMBER ANALYSED FOR PRIMARY OUTCOME: Bottle A n = 29, Bottle B n = 25. PRIMARY OUTCOME: There was no significant difference in weight gain between randomised groups (0-4 weeks Bottle A 0.74 (SD 1.2) SDS versus bottle B 0.51 (0.39), mean difference 0.23 (95% CI -0.31 to 0.77). SECONDARY OUTCOMES: Infants using bottle A had significantly less reported fussing (mean 46 versus 74 minutes/day, p < 0.05) than those using bottle B. There was no significant difference in any other outcome measure. BREAST-FED REFERENCE GROUP: There were no significant differences in primary or secondary outcomes between breast-fed and formula fed infants. The likelyhood of breastfeeding at 3 months was not significantly different in infants subsequently randomised to bottle A or B. CONCLUSION: Bottle design may have short-term effects on infant behaviour which merit further investigation. No significant effects were seen on milk intake or growth; confidence in these findings is limited by the small sample size and this needs confirmation in a larger study. TRIAL REGISTRATION: Clinical Trials.gov NCT00325208.
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spelling pubmed-33282862012-04-18 Infant feeding bottle design, growth and behaviour: results from a randomised trial Fewtrell, MS Kennedy, K Nicholl, R Khakoo, A Lucas, A BMC Res Notes Research Article BACKGROUND: Whether the design of an anti-vacuum infant feeding bottle influences infant milk intake, growth or behavior is unknown, and was the subject of this randomized trial. METHODS: SUBJECTS: 63 (36 male) healthy, exclusively formula-fed term infants. INTERVENTION: Randomisation to use Bottle A (n = 31), one-way air valve: Philips Avent) versus Bottle B (n = 32), internal venting system: Dr Browns). 74 breast-fed reference infants were recruited, with randomisation (n = 24) to bottle A (n = 11) or B (n = 13) if bottle-feeding was subsequently introduced. RANDOMISATION: stratified by gender and parity; computer-based telephone randomisation by independent clinical trials unit. SETTING: Infant home. PRIMARY OUTCOME MEASURE: infant weight gain to 4 weeks. SECONDARY OUTCOMES: (i) milk intake (ii) infant behaviour measured at 2 weeks (validated 3-day diary); (iii) risk of infection; (iv) continuation of breastfeeding following introduction of mixed feeding. RESULTS: NUMBER ANALYSED FOR PRIMARY OUTCOME: Bottle A n = 29, Bottle B n = 25. PRIMARY OUTCOME: There was no significant difference in weight gain between randomised groups (0-4 weeks Bottle A 0.74 (SD 1.2) SDS versus bottle B 0.51 (0.39), mean difference 0.23 (95% CI -0.31 to 0.77). SECONDARY OUTCOMES: Infants using bottle A had significantly less reported fussing (mean 46 versus 74 minutes/day, p < 0.05) than those using bottle B. There was no significant difference in any other outcome measure. BREAST-FED REFERENCE GROUP: There were no significant differences in primary or secondary outcomes between breast-fed and formula fed infants. The likelyhood of breastfeeding at 3 months was not significantly different in infants subsequently randomised to bottle A or B. CONCLUSION: Bottle design may have short-term effects on infant behaviour which merit further investigation. No significant effects were seen on milk intake or growth; confidence in these findings is limited by the small sample size and this needs confirmation in a larger study. TRIAL REGISTRATION: Clinical Trials.gov NCT00325208. BioMed Central 2012-03-16 /pmc/articles/PMC3328286/ /pubmed/22424116 http://dx.doi.org/10.1186/1756-0500-5-150 Text en Copyright ©2012 Fewtrell et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fewtrell, MS
Kennedy, K
Nicholl, R
Khakoo, A
Lucas, A
Infant feeding bottle design, growth and behaviour: results from a randomised trial
title Infant feeding bottle design, growth and behaviour: results from a randomised trial
title_full Infant feeding bottle design, growth and behaviour: results from a randomised trial
title_fullStr Infant feeding bottle design, growth and behaviour: results from a randomised trial
title_full_unstemmed Infant feeding bottle design, growth and behaviour: results from a randomised trial
title_short Infant feeding bottle design, growth and behaviour: results from a randomised trial
title_sort infant feeding bottle design, growth and behaviour: results from a randomised trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328286/
https://www.ncbi.nlm.nih.gov/pubmed/22424116
http://dx.doi.org/10.1186/1756-0500-5-150
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