Cargando…

Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology

Advanced aging is associated with reduced attentional control and less flexible information processing. Here, the origins of these cognitive effects were explored using a functional magnetic resonance imaging task that systematically varied demands to shift attention and inhibit irrelevant informati...

Descripción completa

Detalles Bibliográficos
Autores principales: Hedden, Trey, Van Dijk, Koene R. A., Shire, Emily H., Sperling, Reisa A., Johnson, Keith A., Buckner, Randy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328340/
https://www.ncbi.nlm.nih.gov/pubmed/21765181
http://dx.doi.org/10.1093/cercor/bhr172
_version_ 1782229727113641984
author Hedden, Trey
Van Dijk, Koene R. A.
Shire, Emily H.
Sperling, Reisa A.
Johnson, Keith A.
Buckner, Randy L.
author_facet Hedden, Trey
Van Dijk, Koene R. A.
Shire, Emily H.
Sperling, Reisa A.
Johnson, Keith A.
Buckner, Randy L.
author_sort Hedden, Trey
collection PubMed
description Advanced aging is associated with reduced attentional control and less flexible information processing. Here, the origins of these cognitive effects were explored using a functional magnetic resonance imaging task that systematically varied demands to shift attention and inhibit irrelevant information across task blocks. Prefrontal and parietal regions previously implicated in attentional control were recruited by the task and most so for the most demanding task configurations. A subset of older individuals did not modulate activity in frontal and parietal regions in response to changing task requirements. Older adults who did not dynamically modulate activity underperformed their peers and scored more poorly on neuropsychological measures of executive function and speed of processing. Examining 2 markers of preclinical pathology in older adults revealed that white matter hyperintensities (WMHs), but not high amyloid burden, were associated with failure to modulate activity in response to changing task demands. In contrast, high amyloid burden was associated with alterations in default network activity. These results suggest failure to modulate frontal and parietal activity reflects a disruptive process in advanced aging associated with specific neuropathologic processes.
format Online
Article
Text
id pubmed-3328340
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-33283402012-04-18 Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology Hedden, Trey Van Dijk, Koene R. A. Shire, Emily H. Sperling, Reisa A. Johnson, Keith A. Buckner, Randy L. Cereb Cortex Articles Advanced aging is associated with reduced attentional control and less flexible information processing. Here, the origins of these cognitive effects were explored using a functional magnetic resonance imaging task that systematically varied demands to shift attention and inhibit irrelevant information across task blocks. Prefrontal and parietal regions previously implicated in attentional control were recruited by the task and most so for the most demanding task configurations. A subset of older individuals did not modulate activity in frontal and parietal regions in response to changing task requirements. Older adults who did not dynamically modulate activity underperformed their peers and scored more poorly on neuropsychological measures of executive function and speed of processing. Examining 2 markers of preclinical pathology in older adults revealed that white matter hyperintensities (WMHs), but not high amyloid burden, were associated with failure to modulate activity in response to changing task demands. In contrast, high amyloid burden was associated with alterations in default network activity. These results suggest failure to modulate frontal and parietal activity reflects a disruptive process in advanced aging associated with specific neuropathologic processes. Oxford University Press 2012-05 2011-07-17 /pmc/articles/PMC3328340/ /pubmed/21765181 http://dx.doi.org/10.1093/cercor/bhr172 Text en © The Authors 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Hedden, Trey
Van Dijk, Koene R. A.
Shire, Emily H.
Sperling, Reisa A.
Johnson, Keith A.
Buckner, Randy L.
Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology
title Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology
title_full Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology
title_fullStr Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology
title_full_unstemmed Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology
title_short Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology
title_sort failure to modulate attentional control in advanced aging linked to white matter pathology
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328340/
https://www.ncbi.nlm.nih.gov/pubmed/21765181
http://dx.doi.org/10.1093/cercor/bhr172
work_keys_str_mv AT heddentrey failuretomodulateattentionalcontrolinadvancedaginglinkedtowhitematterpathology
AT vandijkkoenera failuretomodulateattentionalcontrolinadvancedaginglinkedtowhitematterpathology
AT shireemilyh failuretomodulateattentionalcontrolinadvancedaginglinkedtowhitematterpathology
AT sperlingreisaa failuretomodulateattentionalcontrolinadvancedaginglinkedtowhitematterpathology
AT johnsonkeitha failuretomodulateattentionalcontrolinadvancedaginglinkedtowhitematterpathology
AT bucknerrandyl failuretomodulateattentionalcontrolinadvancedaginglinkedtowhitematterpathology