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Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology
Advanced aging is associated with reduced attentional control and less flexible information processing. Here, the origins of these cognitive effects were explored using a functional magnetic resonance imaging task that systematically varied demands to shift attention and inhibit irrelevant informati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328340/ https://www.ncbi.nlm.nih.gov/pubmed/21765181 http://dx.doi.org/10.1093/cercor/bhr172 |
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author | Hedden, Trey Van Dijk, Koene R. A. Shire, Emily H. Sperling, Reisa A. Johnson, Keith A. Buckner, Randy L. |
author_facet | Hedden, Trey Van Dijk, Koene R. A. Shire, Emily H. Sperling, Reisa A. Johnson, Keith A. Buckner, Randy L. |
author_sort | Hedden, Trey |
collection | PubMed |
description | Advanced aging is associated with reduced attentional control and less flexible information processing. Here, the origins of these cognitive effects were explored using a functional magnetic resonance imaging task that systematically varied demands to shift attention and inhibit irrelevant information across task blocks. Prefrontal and parietal regions previously implicated in attentional control were recruited by the task and most so for the most demanding task configurations. A subset of older individuals did not modulate activity in frontal and parietal regions in response to changing task requirements. Older adults who did not dynamically modulate activity underperformed their peers and scored more poorly on neuropsychological measures of executive function and speed of processing. Examining 2 markers of preclinical pathology in older adults revealed that white matter hyperintensities (WMHs), but not high amyloid burden, were associated with failure to modulate activity in response to changing task demands. In contrast, high amyloid burden was associated with alterations in default network activity. These results suggest failure to modulate frontal and parietal activity reflects a disruptive process in advanced aging associated with specific neuropathologic processes. |
format | Online Article Text |
id | pubmed-3328340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33283402012-04-18 Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology Hedden, Trey Van Dijk, Koene R. A. Shire, Emily H. Sperling, Reisa A. Johnson, Keith A. Buckner, Randy L. Cereb Cortex Articles Advanced aging is associated with reduced attentional control and less flexible information processing. Here, the origins of these cognitive effects were explored using a functional magnetic resonance imaging task that systematically varied demands to shift attention and inhibit irrelevant information across task blocks. Prefrontal and parietal regions previously implicated in attentional control were recruited by the task and most so for the most demanding task configurations. A subset of older individuals did not modulate activity in frontal and parietal regions in response to changing task requirements. Older adults who did not dynamically modulate activity underperformed their peers and scored more poorly on neuropsychological measures of executive function and speed of processing. Examining 2 markers of preclinical pathology in older adults revealed that white matter hyperintensities (WMHs), but not high amyloid burden, were associated with failure to modulate activity in response to changing task demands. In contrast, high amyloid burden was associated with alterations in default network activity. These results suggest failure to modulate frontal and parietal activity reflects a disruptive process in advanced aging associated with specific neuropathologic processes. Oxford University Press 2012-05 2011-07-17 /pmc/articles/PMC3328340/ /pubmed/21765181 http://dx.doi.org/10.1093/cercor/bhr172 Text en © The Authors 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Hedden, Trey Van Dijk, Koene R. A. Shire, Emily H. Sperling, Reisa A. Johnson, Keith A. Buckner, Randy L. Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology |
title | Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology |
title_full | Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology |
title_fullStr | Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology |
title_full_unstemmed | Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology |
title_short | Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology |
title_sort | failure to modulate attentional control in advanced aging linked to white matter pathology |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328340/ https://www.ncbi.nlm.nih.gov/pubmed/21765181 http://dx.doi.org/10.1093/cercor/bhr172 |
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