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The Effect of Preterm Birth on Thalamic and Cortical Development

Preterm birth is a leading cause of cognitive impairment in childhood and is associated with cerebral gray and white matter abnormalities. Using multimodal image analysis, we tested the hypothesis that altered thalamic development is an important component of preterm brain injury and is associated w...

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Autores principales: Ball, Gareth, Boardman, James P., Rueckert, Daniel, Aljabar, Paul, Arichi, Tomoki, Merchant, Nazakat, Gousias, Ioannis S., Edwards, A. David, Counsell, Serena J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328341/
https://www.ncbi.nlm.nih.gov/pubmed/21772018
http://dx.doi.org/10.1093/cercor/bhr176
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author Ball, Gareth
Boardman, James P.
Rueckert, Daniel
Aljabar, Paul
Arichi, Tomoki
Merchant, Nazakat
Gousias, Ioannis S.
Edwards, A. David
Counsell, Serena J.
author_facet Ball, Gareth
Boardman, James P.
Rueckert, Daniel
Aljabar, Paul
Arichi, Tomoki
Merchant, Nazakat
Gousias, Ioannis S.
Edwards, A. David
Counsell, Serena J.
author_sort Ball, Gareth
collection PubMed
description Preterm birth is a leading cause of cognitive impairment in childhood and is associated with cerebral gray and white matter abnormalities. Using multimodal image analysis, we tested the hypothesis that altered thalamic development is an important component of preterm brain injury and is associated with other macro- and microstructural alterations. T(1)- and T(2)-weighted magnetic resonance images and 15-direction diffusion tensor images were acquired from 71 preterm infants at term-equivalent age. Deformation-based morphometry, Tract-Based Spatial Statistics, and tissue segmentation were combined for a nonsubjective whole-brain survey of the effect of prematurity on regional tissue volume and microstructure. Increasing prematurity was related to volume reduction in the thalamus, hippocampus, orbitofrontal lobe, posterior cingulate cortex, and centrum semiovale. After controlling for prematurity, reduced thalamic volume predicted: lower cortical volume; decreased volume in frontal and temporal lobes, including hippocampus, and to a lesser extent, parietal and occipital lobes; and reduced fractional anisotropy in the corticospinal tracts and corpus callosum. In the thalamus, reduced volume was associated with increased diffusivity. This demonstrates a significant effect of prematurity on thalamic development that is related to abnormalities in allied brain structures. This suggests that preterm delivery disrupts specific aspects of cerebral development, such as the thalamocortical system.
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spelling pubmed-33283412012-04-18 The Effect of Preterm Birth on Thalamic and Cortical Development Ball, Gareth Boardman, James P. Rueckert, Daniel Aljabar, Paul Arichi, Tomoki Merchant, Nazakat Gousias, Ioannis S. Edwards, A. David Counsell, Serena J. Cereb Cortex Articles Preterm birth is a leading cause of cognitive impairment in childhood and is associated with cerebral gray and white matter abnormalities. Using multimodal image analysis, we tested the hypothesis that altered thalamic development is an important component of preterm brain injury and is associated with other macro- and microstructural alterations. T(1)- and T(2)-weighted magnetic resonance images and 15-direction diffusion tensor images were acquired from 71 preterm infants at term-equivalent age. Deformation-based morphometry, Tract-Based Spatial Statistics, and tissue segmentation were combined for a nonsubjective whole-brain survey of the effect of prematurity on regional tissue volume and microstructure. Increasing prematurity was related to volume reduction in the thalamus, hippocampus, orbitofrontal lobe, posterior cingulate cortex, and centrum semiovale. After controlling for prematurity, reduced thalamic volume predicted: lower cortical volume; decreased volume in frontal and temporal lobes, including hippocampus, and to a lesser extent, parietal and occipital lobes; and reduced fractional anisotropy in the corticospinal tracts and corpus callosum. In the thalamus, reduced volume was associated with increased diffusivity. This demonstrates a significant effect of prematurity on thalamic development that is related to abnormalities in allied brain structures. This suggests that preterm delivery disrupts specific aspects of cerebral development, such as the thalamocortical system. Oxford University Press 2012-05 2011-07-19 /pmc/articles/PMC3328341/ /pubmed/21772018 http://dx.doi.org/10.1093/cercor/bhr176 Text en © The Authors 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Ball, Gareth
Boardman, James P.
Rueckert, Daniel
Aljabar, Paul
Arichi, Tomoki
Merchant, Nazakat
Gousias, Ioannis S.
Edwards, A. David
Counsell, Serena J.
The Effect of Preterm Birth on Thalamic and Cortical Development
title The Effect of Preterm Birth on Thalamic and Cortical Development
title_full The Effect of Preterm Birth on Thalamic and Cortical Development
title_fullStr The Effect of Preterm Birth on Thalamic and Cortical Development
title_full_unstemmed The Effect of Preterm Birth on Thalamic and Cortical Development
title_short The Effect of Preterm Birth on Thalamic and Cortical Development
title_sort effect of preterm birth on thalamic and cortical development
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328341/
https://www.ncbi.nlm.nih.gov/pubmed/21772018
http://dx.doi.org/10.1093/cercor/bhr176
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