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Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

Notch plays critical roles in both cell fate decisions and tumorigenesis. Notch receptor engagement initiates signaling cascades that include a phosphatidylinositol 3-kinase/target of rapamycin (TOR) pathway. Mammalian TOR (mTOR) participates in two distinct biochemical complexes, mTORC1 and mTORC2,...

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Detalles Bibliográficos
Autores principales:	Lee, Keunwook, Nam, Ki Taek, Cho, Sung Hoon, Gudapati, Prathyusha, Hwang, Yoonha, Park, Do-Sim, Potter, Ross, Chen, Jin, Volanakis, Emmanuel, Boothby, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328370/ https://www.ncbi.nlm.nih.gov/pubmed/22473959 http://dx.doi.org/10.1084/jem.20111470

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