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Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

Nonproteolytic ubiquitylation of chromatin surrounding deoxyribonucleic acid double-strand breaks (DSBs), mediated by the RNF8/RNF168 ubiquitin ligases, plays a key role in recruiting repair factors, including 53BP1 and BRCA1, to reestablish genome integrity. In this paper, we show that human RNF169...

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Detalles Bibliográficos
Autores principales:	Poulsen, Maria, Lukas, Claudia, Lukas, Jiri, Bekker-Jensen, Simon, Mailand, Niels
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328375/ https://www.ncbi.nlm.nih.gov/pubmed/22492721 http://dx.doi.org/10.1083/jcb.201109100

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